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Multicenter Study
. 2024 Dec 30;14(1):31811.
doi: 10.1038/s41598-024-83100-4.

The association Malnutrition-Inflammation Score with chronic kidney disease-associated pruritus and quality of life in hemodialysis patients: a multicenter cross-sectional study

Hossein Bavi Behbahani  1   2 , Meysam Alipour  1 , Ahmad Zare Javid  2 , Hamidreza Razmi  3   4 , Pardis Tofighzadeh  5 , Fatemeh Fayazfar  6 , Sara Keramatzadeh  5 , Shiva Shokri  6 , Haleh Soltaniyan Dehkordi  7 , Kian Khosravi  7 , Siavash Babajafari Esfandabad  8 , Shokouh Shayanpour  9
Affiliations
Multicenter Study

The association Malnutrition-Inflammation Score with chronic kidney disease-associated pruritus and quality of life in hemodialysis patients: a multicenter cross-sectional study

Hossein Bavi Behbahani et al. Sci Rep. .

Abstract

Malnutrition is prevalent among hemodialysis patients, negatively impacting their quality of life (QoL) and chronic kidney disease-associated pruritus (CKD-aP). This study investigates the association between the Malnutrition-Inflammation Score (MIS) and CKD-aP, as well as QoL, in hemodialysis patients. This cross-sectional study was conducted on 479 HD patients (279 males and 200 females) referred to eight dialysis centers. A food frequency questionnaire (FFQ), Kidney Disease Quality of Life Short Form (KDQOL-SF™), and Yosipovitch Itch Questionnaire (YIQ) were used to assess nutritional status, QoL, and CKD-aP, respectively. Anthropometric indices, body mass index (BMI), biochemical parameters, and adequacy of dialysis (Kt/V) were also measured in all patients. Significant differences were observed across MIS quartiles in terms of age, dialysis vintage, dialysis time, and urine volume (p < 0.05 for all). QoL scores showed significant differences, with the physical component score and symptoms/problems score being lower in higher MIS quartiles (p < 0.05 for all). Multivariate analyses revealed that higher MIS quartiles were significantly associated with worse QoL scores, including symptoms/problems and physical component scores, even after adjusting for confounders (p < 0.05 for all). Moreover, the pruritus VAS score, as well as the burden of kidney disease and mental component, had a significant negative association with MIS after adjusting for confounders (p < 0.05 for all). This study demonstrates that higher MIS, indicating poorer nutritional status, is associated with impaired QoL, particularly in the symptoms/problems, physical, and mental components among hemodialysis patients. However, no significant association was found between MIS and CKD-aP.

Keywords: CKD-aP; Hemodialysis; Malnutrition-Inflammation Score; Pruritus; Quality of life.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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