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. 2024 Dec 30;29(1):34.
doi: 10.1007/s00784-024-06119-x.

Platelet-rich fibrin application after mandibular third molar extraction: an umbrella review

Hao Yang  1 , Jinghong Yu  2 , Dongxue Wu  3
Affiliations

Platelet-rich fibrin application after mandibular third molar extraction: an umbrella review

Hao Yang et al. Clin Oral Investig. .

Abstract

Objectives: The aim of this study was evaluate the effect of Platelet-Rich Fibrin (PRF) in patients after mandibular third molar extraction through an analysis of the most current literature on systematic reviews and meta-analyses.

Data, sources and study selection: By using computer-assisted search technology, we comprehensively searched several reliable databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, the Chinese biomedical literature database, PubMed, Web of Science, EMBase, and the Cochrane Library, and performed a systematic retrospective meta-analysis on all of the collected studies on the therapeutic effects of PRF on patients after mandibular third molar extraction. A total of nine meta-analyses were performed in this study, and all nine studies were rated as high quality on the basis of the AMSTAR 2 criteria. Seven outcome indicators were extracted from the nine meta-analyses.

Conclusion: According to the included studies, which all demonstrated high scientific quality, PRF application after mandibular third molar extraction significantly reduces postoperative pain and inflammation, accelerates soft tissue healing, and effectively lowers the incidence of complications such as dry socket and alveolar osteitis. However, PRF did not significantly affect trismus or bone density. The conclusion has reliable support and clinical significance.

Keywords: Mandibular third molar extraction; Platelet-rich fibrin; Umbrella review.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Clinical trial number: Not applicable. Conflict of interest: The authors declare no conflict of interest related to this research paper. Competing interests: The authors declare no competing interests.

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