Pregnancy with Wilson's Disease: A Case Series

Abstract

Wilson's disease is an autosomal recessive disorder that affects copper transport due to deficiency of ceruloplasmin and causes deposition of copper mainly in the liver, brain and cornea. It causes hepatic and/or neuropsychiatric manifestations. This copper deposition causes cirrhosis of the liver, encephalopathy and liver failure. It also causes disorders of the menstrual cycle and subfertility. During pregnancy, there is an increased risk of the development of preeclampsia, fetal growth restriction, and neurologic damages to the fetus. Pregnancy with decompensated liver cirrhosis developed more complications like bleeding from esophageal varices, liver failure, encephalopathy, and rupture of the splenic artery. A successful decopperizing agent may lead to restoration of the ovulatory cycle and enable pregnancy. We are reporting four cases of successful pregnancy outcomes of known case of Wilson's disease with pregnancy which was taken from Fetomaternal Medicine Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), and discussing the management of pregnant women with this disorder.