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. 1985 Apr;54(1):219-23.
doi: 10.1128/JVI.54.1.219-223.1985.

Persistence of echovirus 6 in cloned human cells

J P Gibson, V F Righthand

Persistence of echovirus 6 in cloned human cells

J P Gibson et al. J Virol. 1985 Apr.

Abstract

Establishment of a persistent infection by echovirus 6 in cloned human WISH cells (PI) was demonstrated. The cloned human WISH cells were maintained for 3.0 years (over 125 passages) and released virus continuously without cellular destruction. Neither temperature-sensitive virus mutants nor interferon appears to play a role in either establishment or maintenance of viral persistence. The majority of the virus produced by cloned human WISH cells is defective (2 X 10(6) particles per PFU) and differs from standard virus in its polypeptide profile and its inability to attach to parental WISH cells.

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