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. 2024 Dec 31;24(1):962.
doi: 10.1186/s12888-024-06434-3.

Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress

Xinxin Zhao  1 , Hongzhe Ma  2 , Ning Li  2 , Wenjun Wu  2 , Xinxu Ma  2 , Xinxin Zhang  1 , Wenming Liu  2 , Lei Shang  3 , Huaning Wang  2 , Hailong Dong  1 , Chen Li  3 , Guangchao Zhao  4 , Min Cai  5
Affiliations

Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress

Xinxin Zhao et al. BMC Psychiatry. .

Abstract

Background: Major depressive disorder (MDD) is a highly prevalent mental disorder with devastating consequences that often first manifest during adolescence. Anhedonia has emerged as one of the most promising symptoms of adolescent MDD, which means a longer time to remission， fewer depression-free days, and also increased risk of suicide ideas or actions. Research has shown that at least two-thirds of depressed adolescents have significant sleep-onset or sleep-maintenance problems. However, the association between sleep disorder and anhedonia, and the potential mediators are less understood.

Methods: This is a cross-sectional study that includes 200 adolescents suffered from MDD between the ages of 12-17. We use Spearman's test to explore the relationship among main variables. To evaluate the mediating effects of stress, we applied regression models and used bootstrap method to validate the significance of effects.

Results: Significant correlation exists among sleep disorder, stress, and anhedonia (P<0.05).The direct effect of sleep disorder on anhedonia was 0.214 (95% CI: 1.5235, 6.2073), while the total effect was 0.295 (95% CI: 2.9683, 7.6924). The indirect effect of sleep disorder on anhedonia mediated by stress was 0.081 (95% CI: 0.5842, 2.5268). Robustness of the regression analysis results has been verified by bootstrap test.

Conclusions: Our finding suggested a positive correlation between sleep disturbance and anhedonia in adMDD. Stress partially mediated the relationship between sleep disorder and anhedonia. Due to the deleterious effects of anhedonia on depressed adolescents, these findings provide impetus to investigate further the causal relationship between sleep problems and anhedonia.

Trial registration: ChiCTR2200060176(Registration Date: 21/05/2022).

Keywords: Adolescent; Anhedonia; Cross-sectional study; Major depression disorder; Sleep disorder; Stress.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was approved by the institutional ethics committee of the Ethics Committee of Xijing Hospital of the Fourth Military Medical University (KY20222058-F-1) and registered in Chinese Clinical Trial Registration Center (ChiCTR2200060176; Registration Date: 21/05/2022). All participants and their legal guardians gave informed consent before enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between sleep disorder, stress and anhedonia
See this image and copyright information in PMC

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