Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Dec 18:14:1462353.
doi: 10.3389/fonc.2024.1462353. eCollection 2024.

Primary uterine non-Hodgkin's lymphoma:a rare case report and review of the literature

Jing Wu  1 , Ting Liu  1
Affiliations
Case Reports

Primary uterine non-Hodgkin's lymphoma:a rare case report and review of the literature

Jing Wu et al. Front Oncol. .

Abstract

Primary uterine non-Hodgkin lymphoma (NHL) is rarely reported, as its incidence is extremely low. We describe a 72 year old patient with primary uterine non-Hodgkin's lymphoma stage IV, diffuse B-cell large cells, who responded well to cytotoxic chemotherapy (R-CHOP). Radiological investigations exhibited certain characteristics, including magnetic resonance T2 weighted imaging, enhanced scanning, diffusion weighted imaging and apparent diffusion coefficient values. The lesion in the anterior wall of the uterine body was relatively large, with a size of about 34mm×47mm×43mm. The gold standard for diagnosis is still the pathological examination of a biopsy specimen, which revealed diffuse large cell of B lineage. This article reviews data collected from 141 patients in the literature.

Keywords: diffuse large b-cell lymphoma (DLBCL); diffusion weighted imaging; magnetic resonance (MR) imaging; non Hodgkin lymphoma (NHL); primary uterine non-Hodgkin lymphoma (NHL).

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Magnetic resonance imaging scans of an 72-year-old female patient with a pelvic mass showed the following: (A, B, D, E) an enlarged uterus; (F) the arterial phase enhancement of the lesion was significantly uneven, the degree of venous phase enhancement was lower than that of the normal uterine myometrium. (C) The apparent diffusion coefficient (ADC) value of uterine mass was 0.751×10-3 mm2/s.
Figure 2
Figure 2
Computed tomography (CT) imaging scans of an 72-year-old female patient with a pelvic mass for more than 1 month: (A) plain CT imaging showed an enlarged uterine volume, soft tissue density shadow in the anterior wall of the uterus, with unclear boundary; (B–D) enhanced CT imaging(arterial phase[b]; venous phase[c]; delay phase[d]) showed that the lesion were slightly enhanced, the boundary was clear; (E–H) after treatment, enhanced CT imaging(arterial phase[f]; venous phase[g]; delay phase[h]) showed that the volume of the uterus had significantly reduced(plain CT imaging[e]).
Figure 3
Figure 3
HE staining of the specimen (×40) (A), (×200) (B), and immunohistochemical examination revealed CD10 (+) (C), CD20 (+) (D), Bcl-6 (+) (E), CD3(+) (F), C-myc(+) (G), Ki-67(+) (H), LCA(+) (I), MUM1(+) (J), P53(+) (K), Pax-5(+) (L), Vimentin(+) (M) and suggested a diffuse large B-cell lymphoma. HE, hematoxylin.
See this image and copyright information in PMC

References

    1. Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, Holcomb K. Primary lymphoma of the female genital tract: an analysis of 697 cases. Gynecol Oncol. (2017) 145:305–9. doi: 10.1016/j.ygyno.2017.02.043 - DOI - PubMed
    1. Frey NV, Svoboda J, Andreadis C, Tsai DE, Schuster SJ, Elstrom R, et al. . Primary lymphomas of the cervix and uterus: the University of Pennsylvania’s experience and a review of the literature. Leuk Lymphoma. (2006) 47:1894–901. doi: 10.1080/10428190600687653 - DOI - PubMed
    1. Li S, Young KH, Medeiros LJ. Diffuse large B-cell lymphoma. Pathology. (2018) 50:74–87. doi: 10.1016/j.pathol.2017.09.006 - DOI - PubMed
    1. Hamlin PA, Satram-Hoang S, Reyes C, Hoang KQ, Guduru SR, Skettino S. Treatment patterns and comparative effectiveness in elderly diffuse large B-cell lymphoma patients: a surveillance, epidemiology, and end results-medicare analysis. Oncologist. (2014) 19:1249–57. doi: 10.1634/theoncologist.2014-0113 - DOI - PMC - PubMed
    1. Pinto E, Batista S, Lourenc C, Gonçalves J, Ramalho G. Gynecological lymphomas Linfomas ginecologicos. Acta Obstet Ginecol Port. (2014) 8:201–5.

Publication types

LinkOut - more resources