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Review
. 2024 Dec 18:15:1516650.
doi: 10.3389/fphar.2024.1516650. eCollection 2024.

Metabolic reprogramming in lung cancer and its clinical implication

Qingqiu Huang #  1 , Lisha Fan #  2 , Mingjing Gong #  3 , Juntong Ren  4 , Chen Chen  5 , Shenglong Xie  1
Affiliations
Review

Metabolic reprogramming in lung cancer and its clinical implication

Qingqiu Huang et al. Front Pharmacol. .

Abstract

Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.

Keywords: amino acid metabolism; glucose; lipid metabolism; lung cancer; metabolic reprogramming.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Warburg effect: Differences in energy metabolism between normal nuclear lung cancer cells under aerobic and hypoxic conditions.
FIGURE 2
FIGURE 2
Glucose metabolism in lung cancer: important transporters and rate-limiting enzymes in glucose metabolism, as well as relevant literature in lung cancer research.
FIGURE 3
FIGURE 3
Transport of fatty acid and their transporters. The function of fatty acid transporters (CD36 and FABP) and relevant literature in lung cancer research.
FIGURE 4
FIGURE 4
Fatty acid synthesis in lung Cancer. The important transcription factor SREBPs and rate-limiting enzymes in fatty acid synthesis, as well as relevant literature in lung cancer research.
FIGURE 5
FIGURE 5
Cystine metabolism and redox equilibrium. Cystine is vital for redox regulation in cancer metabolism and cell survival.
See this image and copyright information in PMC

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References

    1. Abumrad N. A., Cabodevilla A. G., Samovski D., Pietka T., Basu D., Goldberg I. J. (2021). Endothelial cell receptors in tissue lipid uptake and metabolism. Circ. Res. 128, 433–450. 10.1161/CIRCRESAHA.120.318003 - DOI - PMC - PubMed
    1. Altman B. J., Stine Z. E., Dang C. V. (2016). From Krebs to clinic: glutamine metabolism to cancer therapy. Nat. Rev. Cancer 16, 619–634. 10.1038/nrc.2016.71 - DOI - PMC - PubMed
    1. Ao Y.-Q., Gao J., Zhang L.-X., Deng J., Wang S., Lin M., et al. (2023). Tumor-infiltrating CD36+CD8+T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer. BMC Cancer 23, 367. 10.1186/s12885-023-10836-z - DOI - PMC - PubMed
    1. Arren B.-E., Avi F., Elad N., Ron M. (2012). Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat. Chem. Biol., 8. 10.1038/nchembio.971 - DOI - PubMed
    1. Azhar M., Xu C., Jiang X., Li W., Cao Y., Zhu X., et al. (2023). The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility. Nucleic Acids Res. 51, 10428–10450. 10.1093/nar/gkad769 - DOI - PMC - PubMed

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