Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 May 7:10:e2024.345242.1542.
doi: 10.22034/CMM.2024.345242.1542. eCollection 2024.

Candida glabrata meningitis in a patient with newly diagnosed acquired immunodeficiency syndrome from Sikkim, India

Sunu Hangma Subba  1 , Tara Devi Sharma  1 , Yeshi Palden Dopthapa  1 , Ugen Gyatso N Bhutia  2 , Rekha Sharma  3
Affiliations
Case Reports

Candida glabrata meningitis in a patient with newly diagnosed acquired immunodeficiency syndrome from Sikkim, India

Sunu Hangma Subba et al. Curr Med Mycol. .

Abstract

Background and purpose: Candida infections in India have shifted, with an increase in the incidence rate of invasive candidiasis, particularly due to non-albicans species. The central nervous system infections by Candida glabrata are sparsely reported and more understanding and research is needed regarding these infections.

Case report: This study reported an unusual case of C. glabrata meningitis in a middle-aged female with pulmonary tuberculosis and newly diagnosed acquired immunodeficiency syndrome with a low cluster of differentiation 4 count (12 cells/mm3). Initially, the patient was treated with fluconazole. Subsequently, the patient underwent therapy involving amphotericin B and flucytosine. The cerebrospinal fluid cultures eventually grew C. glabrata, confirmed by matrix-assisted laser desorption ionization time-of-flight analysis. Despite switching to amphotericin B and flucytosine, the conditions of the patient deteriorated, leading to her death.

Conclusion: Candida glabrata candidemia requires meticulous and vigilant management due to its high mortality rate and relatively higher resistance to azoles, particularly fluconazole. This case underscored the severe and pressing challenges in the management of C. glabrata meningitis, particularly in immunocompromised patients.

Keywords: Acquired immune deficiency syndrome; Candidemia; Central nervous system infections; Fungal meningitis; Candida glabrata.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Chakrabarti A, Chatterjee SS, Shivaprakash MR. Overview of opportunistic fungal infections in India. Nihon Ishinkin Gakkai Zasshi. 2008;49(3):165–72. - PubMed
    1. Herrera S., Pavone P., Kumar D. Chronic Candida dubliniensis meningitis in a lung transplant recipient. Med Mycol Case Rep. (2019); 24:41–3. - PMC - PubMed
    1. Tsakiri S, Aneji C, Domonoske C, Mazur L, Benjamin DK Jr, Wootton SH. Voriconazole Treatment for an Infant with Intractable Candida glabrata Meningitis. Pediatr Infect Dis J. 2018;37(10):999–1001. - PubMed
    1. Goldani LZ, Santos RP. Candida tropicalis as an emerging pathogen in Candida meningitis: case report and review. Braz J Infect Dis. 2010;14(6):631–3. - PubMed
    1. Fidel PL Jr, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999;12(1):80–96. - PMC - PubMed

Publication types

LinkOut - more resources