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. 2024 Dec 30:00185787241309254.
doi: 10.1177/00185787241309254. Online ahead of print.

Ensuring the Safety of Locally Sourced Alcohols for Hand Sanitizer Production During the SARS-CoV-2 Crisis: A Comprehensive Impurity Analysis

Camille Jurado  1 , Zoubeir Ramjaun  1 , Souleiman El Balkhi  2 , Franck Saint-Marcoux  2 , Mathieu Alonso  1 , Anne Sophie Salabert  1 , Fanny Durand  1 , Laetitia Caturla  1 , David Metsu  3 , Emilie Gardes  1 , Isabelle Quelven-Bertin  1 , Philippe Cestac  1
Affiliations

Ensuring the Safety of Locally Sourced Alcohols for Hand Sanitizer Production During the SARS-CoV-2 Crisis: A Comprehensive Impurity Analysis

Camille Jurado et al. Hosp Pharm. .

Abstract

Amid the early 2020 SARS-CoV-2 crisis, severe hand sanitizer shortages led to OMS local production recommendations, inviting a diverse array of alcohol producers to contribute. However, not all followed mandatory controls for API-grade alcohol. We conducted a study to ensure the safety of the received alcohols, focusing on methanol and acetaldehyde levels. All samples were well below Ph. Eur guidelines, affirming their safety for use. Furthermore, no additional impurities were detected, reinforcing the quality and safety of the assessed hand sanitizers. Our findings, amidst the scarcity of the SARS-CoV-2 era, highlight the importance of rigorous safety assessments during local hand sanitizer production.

Keywords: SARS-CoV-2; acetaldehyde; alcohol-based hand sanitizer; methanol.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Lachenmeier DW. Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity. J Occup Med Toxicol. 2008;3(1):26. doi:10.1186/1745-6673-3-26 - DOI - PMC - PubMed
    1. World Health Organization. World Health Organization - 2020 - WHO Interim Recommendation 1 April 2020. 2020. Accessed December 23, 2024. https://www.who.int/publications/m/item/interim-recommendations-on-oblig...
    1. World Health Organization. WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge: Clean Care is Safer Care, Chapter 12. World Health Organization, Patient Safety; 2009. - PubMed
    1. Berardi A, Perinelli DR, Merchant HA, et al.. Hand sanitisers amid CoViD-19: A Critical Review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int J Pharm. 2020;584:119431. doi:10.1016/j.ijpharm.2020.119431 - DOI - PMC - PubMed
    1. European Directorate for the Quality of Medicines & HealthCare (EDQM). Ethanol 96% v/v. In: European Pharmacopoeia. 11th ed. Strasbourg, France: Council of Europe; 2023.

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