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Review
. 2025 Jan 2;25(1):4.
doi: 10.1007/s10142-024-01509-6.

Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets

JiaJie Wu  1 , Lele Li  1 , Wei Xu  1 , Xiaoping Xia  2 , Yingping Wu  3
Affiliations
Review

Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets

JiaJie Wu et al. Funct Integr Genomics. .

Abstract

Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms. The detection of differentially expressed circRNAs in individuals afflicted with SARS-CoV-2 signifies a noteworthy advancement in understanding the molecular mechanisms underpinning viral pathogenesis.

Keywords: Circular RNAs; Non-coding RNA; RNA treatment; SARS-CoV-2; Virus-host interaction.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Not applicable. Informed consent: Not applicable. Consent to participate: Not applicable. Consent to publication: Not applicable.

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