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Comment
. 2025 Mar 1;11(3):340-342.
doi: 10.1001/jamaoncol.2024.5648.

Transplant-Free Salvage Therapy for Low-Risk Relapsed Pediatric Hodgkin Lymphoma: A Nonrandomized Clinical Trial

Bradford S Hoppe  1 , Sarah A Milgrom  2 , Lindsay A Renfro  3   4 , Yue Wu  4 , Cindy L Schwartz  5 , Louis S Constine  6 , Kathleen M McCarten  7 , Kara M Kelly  8 , David Hodgson  9   10 , Sharon M Castellino  11 , Frank G Keller  11
Affiliations
Comment

Transplant-Free Salvage Therapy for Low-Risk Relapsed Pediatric Hodgkin Lymphoma: A Nonrandomized Clinical Trial

Bradford S Hoppe et al. JAMA Oncol. .
No abstract available

Plain language summary

This nonrandomized clinical trial reports outcomes for children with low-risk relapsed Hodgkin lymphoma treated with second-line chemotherapy and involved-field radiotherapy without autologous stem cell transplant.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Hoppe reported being a member of the scientific advisory committee for Merck and being contracted through the Children’s Oncology Group to the Mayo Clinic outside the submitted work. Dr Milgrom reported working as an unpaid consultant regarding positron emission tomography/computed tomography analyses for Bristol Myers Squibb. Dr Kelly reported grants from the National Cancer Institute during the conduct of the study; grants from Merck, nonfinancial support from BMS and Seagen (both provide study drug for an NCI-funded trial), and grants from the Department of Defense outside the submitted work. Dr Castellino reported personal fees from Seagen Inc during the conduct of the study and outside the submitted work, and personal fees from Bristol Myers Squibb outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Event-Free Survival
Second event-free survival for 32 patients with low-risk relapsed Hodgkin lymphoma and 20 who completed protocol treatment. The shaded areas represent 95% CIs.
See this image and copyright information in PMC

Comment on

References

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