Transforming pain medicine: the power of collaboration, entrepreneurship, and innovation

Salman Hirani^{1

2}, Peter Vu³, Mali Halac⁴, Siri Bohacek¹, Barlas Benkli⁵, David Jevotovsky⁶, Julio Vega⁷, Aliza Hirani⁸, Vwaire Orhurhu⁹, Charles Odonkor¹⁰, Jesse Ehrenfeld¹¹, Iskander Shadid^{2

12}, Amanda Azadian¹³, Brian Mayrsohn¹⁴, Albert Kwon¹⁵, Zishan Hirani^{16

17

18}, Uzondu Osuagwu¹⁹, Justin Bird²⁰, Christopher Gilligan²¹, Beth D Darnall¹⁵, Kayode Williams²², W Michael Hooten²³, Shriya Srinivasan^{2

4}

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
² MIT Hacking Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
³ Department of Physical Medicine and Rehabilitation, University of Texas McGovern Medical School, Houston, TX 77030, United States.
⁴ John A. Paulson School of Engineering & Applied Sciences, Harvard University, Allston, MA 02134, United States.
⁵ Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, United States.
⁶ Department of Physical Medicine & Rehabilitation, NYU Grossman School of Medicine, New York, NY 10016, United States.
⁷ Department of Anesthesia and Perioperative Care, Division of Pain Medicine, University of California San Francisco, San Francisco, CA 94158, United States.
⁸ Department of Psychiatry, Children's Health, Dallas, TX 75235, United States.
⁹ Department of Anesthesia, Critical Care, and Pain Medicine, University of Pittsburgh Medical School, Pittsburg, MA 15213, United States.
¹⁰ Department of Orthopedics and Rehabilitation, Division of Physiatry, Interventional Pain Medicine, Yale University School of Medicine, Yale New Haven Hospital, New Haven, CT 06510, United States.
¹¹ Advancing a Healthier Wisconsin Endowment, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
¹² Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden 2300 RA, The Netherlands.
¹³ Pacific College of Health and Science, New York City, New York, NY 10038, United States.
¹⁴ Maywell Health, New York, NY 10016, United States.
¹⁵ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, United States.
¹⁶ Department of Clinical Science, University of Houston, Houston, TX 77004, United States.
¹⁷ Department of Obstetrics and Gynecology, Kelsey-Seybold Clinic, Houston, TX 77010, United States.
¹⁸ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
¹⁹ Department of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
²⁰ Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
²¹ Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.
²² Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, United States.
²³ Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55905, United States.

PMID: 39745892
PMCID: PMC12046216 (available on 2026-01-02)
DOI: 10.1093/pm/pnae130

Transforming pain medicine: the power of collaboration, entrepreneurship, and innovation

Salman Hirani et al. Pain Med. 2025.

. 2025 May 1;26(5):231-236.

doi: 10.1093/pm/pnae130.

Authors

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
² MIT Hacking Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
³ Department of Physical Medicine and Rehabilitation, University of Texas McGovern Medical School, Houston, TX 77030, United States.
⁴ John A. Paulson School of Engineering & Applied Sciences, Harvard University, Allston, MA 02134, United States.
⁵ Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, United States.
⁶ Department of Physical Medicine & Rehabilitation, NYU Grossman School of Medicine, New York, NY 10016, United States.
⁷ Department of Anesthesia and Perioperative Care, Division of Pain Medicine, University of California San Francisco, San Francisco, CA 94158, United States.
⁸ Department of Psychiatry, Children's Health, Dallas, TX 75235, United States.
⁹ Department of Anesthesia, Critical Care, and Pain Medicine, University of Pittsburgh Medical School, Pittsburg, MA 15213, United States.
¹⁰ Department of Orthopedics and Rehabilitation, Division of Physiatry, Interventional Pain Medicine, Yale University School of Medicine, Yale New Haven Hospital, New Haven, CT 06510, United States.
¹¹ Advancing a Healthier Wisconsin Endowment, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
¹² Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden 2300 RA, The Netherlands.
¹³ Pacific College of Health and Science, New York City, New York, NY 10038, United States.
¹⁴ Maywell Health, New York, NY 10016, United States.
¹⁵ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, United States.
¹⁶ Department of Clinical Science, University of Houston, Houston, TX 77004, United States.
¹⁷ Department of Obstetrics and Gynecology, Kelsey-Seybold Clinic, Houston, TX 77010, United States.
¹⁸ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
¹⁹ Department of Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
²⁰ Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
²¹ Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States.
²² Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, United States.
²³ Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55905, United States.

PMID: 39745892
PMCID: PMC12046216 (available on 2026-01-02)
DOI: 10.1093/pm/pnae130

No abstract available

Keywords: collaboration; innovation; multimodal; pain.

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References

1. Gregorian RS, Gasik A, Kwong WJ, Voeller S, Kavanagh S. Importance of side effects in opioid treatment: a trade-off analysis with patients and physicians. J Pain. 2010;11(11):1095-1108. 10.1016/j.jpain.2010.02.007 - DOI - PubMed
1. Nahin RL, Feinberg T, Kapos FP, Terman GW. Estimated rates of incident and persistent chronic pain among US Adults, 2019-2020. JAMA Netw Open. 2023;6(5):e2313563. 10.1001/jamanetworkopen.2023.13563 - DOI - PMC - PubMed
1. Sudore RL, Karter AJ, Huang ES, et al. Symptom burden of adults with type 2 diabetes across the disease course: diabetes & aging study. J Gen Intern Med. 2012;27(12):1674-1681. 10.1007/s11606-012-2132-3 - DOI - PMC - PubMed
1. Saccò M, Meschi M, Regolisti G, et al. The relationship between blood pressure and pain. J Clin Hypertens (Greenwich). 2013;15(8):600-605. 10.1111/jch.12145 - DOI - PMC - PubMed
1. De La Rosa JS, Brady BR, Ibrahim MM, et al. Co-occurrence of chronic pain and anxiety/depression symptoms in US adults: prevalence, functional impacts, and opportunities. Pain. 2024;165(3):666-673. 10.1097/j.pain.0000000000003056 - DOI - PMC - PubMed

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Transforming pain medicine: the power of collaboration, entrepreneurship, and innovation

Affiliations

Transforming pain medicine: the power of collaboration, entrepreneurship, and innovation

Authors

Affiliations

References

Grants and funding

LinkOut - more resources

Full Text Sources