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Comment
. 2025 Jan 3;387(6729):26-27.
doi: 10.1126/science.adu6125. Epub 2025 Jan 2.

Inherited genome instability

Jayne Y Hehir-Kwa  1 , Geoff Macintyre  2
Affiliations
Comment

Inherited genome instability

Jayne Y Hehir-Kwa et al. Science. .

Abstract

Germline structural variants are a risk factor for pediatric extracranial solid tumors.

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  • Rare germline structural variants increase risk for pediatric solid tumors.
    Gillani R, Collins RL, Crowdis J, Garza A, Jones JK, Walker M, Sanchis-Juan A, Whelan CW, Pierce-Hoffman E, Talkowski ME, Brand H, Haigis K, LoPiccolo J, AlDubayan SH, Gusev A, Crompton BD, Janeway KA, Van Allen EM. Gillani R, et al. Science. 2025 Jan 3;387(6729):eadq0071. doi: 10.1126/science.adq0071. Epub 2025 Jan 3. Science. 2025. PMID: 39745975

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