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Editorial
. 2025 Jan 3;136(1):75-77.
doi: 10.1161/CIRCRESAHA.124.325805. Epub 2025 Jan 2.

Stick to the Script: How Endomucin Keeps the Glycocalyx in Line

Ronald McMillan  1 , Benjamin Rodriguez  2 , Annet Kirabo  1   3   4   5
Affiliations
Editorial

Stick to the Script: How Endomucin Keeps the Glycocalyx in Line

Ronald McMillan et al. Circ Res. .
No abstract available

Keywords: Editorials; glycocalyx; glycoproteins; kidney; vascular diseases.

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Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.. The multifacited role of endomucin.
The Figure summarizes information collected from the literature and depicts the impact of normal versus knockout endomucin expression. In the wild-type mice, the inflammatory response is reduced by increasing the antiadhesive properties of the glycocalyx, in the knockout mice, this is reduced which promotes increased adhesion and infiltration of immune cells. Renal function is impaired in the knockout due to podocyte dysfunction. Cell interactions are disrupted in the knockout mice due to endothelial cell membrane remodeling. Cell morphology is altered in the knockout mice resulting in increased membrane permeability and protein leakage.
See this image and copyright information in PMC

Comment on

References

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