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. 2025 Jan 2;20(1):e0312316.
doi: 10.1371/journal.pone.0312316. eCollection 2025.

Patterns and predictors of mortality in the first 24 hours of admission among children aged 1-59 months admitted at a Regional Referral Hospital in South Western Uganda

Moses Ochora  1 , Stella Kyoyagala  1 , Lydia Kyasimire  1 , Mercy Akambasisa  1 , Margaret Twine  1 , Muna Ahmed  1 , Dan Lutasingwa  1 , Dorah Nampijja  1 , Elias Kumbakumba  1
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Patterns and predictors of mortality in the first 24 hours of admission among children aged 1-59 months admitted at a Regional Referral Hospital in South Western Uganda

Moses Ochora et al. PLoS One. .

Abstract

Most deaths among children under 5 years occur within the first 24 hours of hospital admission from preventable causes such as diarrhea, pneumonia, malaria, and HIV/AIDS. The predictors of these deaths are not yet well documented in our setting. This study aimed to describe the patterns and predictors of these mortalities among children aged 1-59 months at a regional hospital in South Western Uganda. We conducted a prospective cohort study among 208 children aged 1-59 months admitted to Mbarara Regional Referral Hospital. The mortality rate within the first 24 hours was 7.7% (95% CI 4-12) and the median time to death was 7.3(2.62-8.75) hours. Most deaths occurred in infants, with severe pneumonia, severe acute malnutrition, and malaria as leading causes. Factors predicting mortality included admission during the night (AHR: 3.7, 95% CI 1.02-13.53, p-value 0.047) and abnormal neutrophil count(AHR: 3.5, 95% CI 1.10-11.31, p-value 0.034). The study highlights the importance of timely interventions, particularly for infants, and suggests extra monitoring for those admitted at night or with abnormal neutrophil counts.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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