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. 2025 Mar 1;145(3):e107-e116.
doi: 10.1097/AOG.0000000000005814. Epub 2025 Jan 2.

Associated Trends in Obesity and Endometrioid Endometrial Cancer in the United States

Alex A Francoeur  1 , Cheng-I Liao, Jenny Chang, Caitlin R Johnson, Kiran Clair, Krishnansu S Tewari, Daniel S Kapp, John K Chan, Robert E Bristow
Affiliations

Associated Trends in Obesity and Endometrioid Endometrial Cancer in the United States

Alex A Francoeur et al. Obstet Gynecol. .

Abstract

Objective: To evaluate the correlation in temporal trends in obesity and endometrioid endometrial cancer incidence in the United States using two comprehensive national databases.

Methods: This is a cohort study in which data on endometrioid endometrial cancer were obtained from the U.S. Cancer Statistics from 2001 to 2018 and corrected for hysterectomy and pregnancy. Data on obesity were collected from the NHANES (National Health and Nutrition Examination Survey) database from 1988 to 2018. Average annual percentage changes (AAPCs) were used to describe trends. Pearson correlation coefficients ( r ) were calculated to examine the relationship between trends. SEER*Stat 8.3.9.2 and joinpoint regression program 5.2.0 were used for statistical analysis.

Results: From U.S. Cancer Statistics data, 586,742 cases of endometrioid cancer were identified from 2001 to 2018. The average annual increase in endometrioid cancer was as follows: Hispanic 1.37% (95% CI, 1.14-1.60, P <.001), Black 1.30% (95% CI, 1.04-1.57, P <.001), and White -0.17 (95% CI, -0.91 to 0.58, P =.656). Women aged 20-29 years had a 4.48% annual increase (95% CI, 3.72-5.25, P <.001) and women aged 30-39 years had a 3.00% annual increase in rates (95% CI, 2.65-3.36, P <.001). According to the NHANES data, the prevalence of obesity in 2018 in adult women was as follows: Black 56.80%, Hispanic 44.10%, and White 40.90%. An examination of trends by age showed that women aged 20-29 years had the highest annual rise in obesity compared with other age groups (AAPC 7.36%, 95% CI, 4.0-10.8, P <.05). Strong and statistically significant correlations between endometrioid cancer and obesity trends were noted for Black ( r =0.78, P =.01) and Hispanic ( r =0.91, P <.001) women, as well as women aged 20-29 years ( r =0.72, P =.03) and 30-39 years ( r =0.88, P =.001).

Conclusion: The current data demonstrate a temporal association between the increasing incidence of obesity and endometrioid endometrial cancer, and this effect disproportionately affects younger women and Black and Hispanic women.

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Conflict of interest statement

Financial Disclosure Caitlin R. Johnson reports receiving payment from Sutter Health. Krishnansu S. Tewari reports receiving payment for serving on the Speaker's Bureaus for GSK, Merck, Astra Zeneca, Eisia, and Seagen. John K. Chan received funds from Denis Cobb Hale Chair, Angela Wang Johnson & The Fisher Family Funds. He received payment from AbbVie and the NRG/GOG for consortium trial participation. He has ongoing relationships with Agenus, AstraZeneca, Daiichi Sankyo, Eisai, Ethicon, GlaxoSmithKline, Genmab, Immunogen, Karyopharm, Merck, Mersana, MTTI, Myriad, Pfizer, Roche, and Seagen. The other authors did not report any potential conflicts of interest.

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