Disarming the cavalry: targeting neutrophils to limit collateral damage in non-CF bronchiectasis

Omri A Arbiv^{1

2

3}, Bradley S Quon^{4

5}

Affiliations

¹ Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
² Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
³ Clinician-Investigator Program, University of British Columbia, Vancouver, BC, Canada.
⁴ Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada bradley.quon@hli.ubc.ca.
⁵ Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.

Editorial

Omri A Arbiv et al. Eur Respir J. 2025.

. 2025 Jan 2;65(1):2401804.

doi: 10.1183/13993003.01804-2024. Print 2025 Jan.

Omri A Arbiv^{1

2

3}, Bradley S Quon^{4

5}

¹ Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
² Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
³ Clinician-Investigator Program, University of British Columbia, Vancouver, BC, Canada.
⁴ Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada bradley.quon@hli.ubc.ca.
⁵ Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.

No abstract available

Conflict of interest statement

Conflict of interest: The authors do not have any personal or financial relationships related to the content of this editorial.

Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study.
Chalmers JD, Shteinberg M, Mall MA, O'Donnell AE, Watz H, Gupta A, Frahm E, Eleftheraki A, Rauch J, Chotirmall SH, Armstrong AW, Eickholz P, Hasegawa N, Sauter W, McShane PJ. Chalmers JD, et al. Eur Respir J. 2025 Jan 2;65(1):2401551. doi: 10.1183/13993003.01551-2024. Print 2025 Jan. Eur Respir J. 2025. PMID: 39255990 Free PMC article. Clinical Trial.