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. 2025 Jan 2;25(1):1.
doi: 10.1186/s12884-024-07102-w.

Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia

Laure Ponthier  1   2 , Chahrazed El Hamel  3   4 , Perrine Coste Mazeau  5 , Sophie Martinez  5 , Sarah Wehbe  5 , Rachel Froget  4   6 , Catherine Yardin  3   7   8 , Vincent Guigonis  3   4
Affiliations

Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia

Laure Ponthier et al. BMC Pregnancy Childbirth. .

Abstract

Background: Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers.

Methods: Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs.

Results: AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers' and children's AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs.

Conclusion: Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies.

Keywords: AT1-AA; Clinical data; Mothers; Newborns; Preeclampsia.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: All pregnant women gave written informed consent and parental informed consent was obtained for all infants. The study protocol was approved by institutional ethics committee (Comité de Protection des Personnes, Sud-Ouest et Outre-Mer IV, CHU de Limoges, Limoges, France. DC-2011–1264). The authors confirm that they have complied with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of studied population and AT1-AA results
Fig. 2
Fig. 2
The AT1-AA concentration in mothers positive to AT1-AA and their children
Fig. 3
Fig. 3
Comparison of AT1-AA positive and negative children of AT1-AA positive mothers
Fig. 4
Fig. 4
Correlation between positive AT1-AA concentration’s children and mothers
See this image and copyright information in PMC

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