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Comparative Study
. 2025 Jan 2;25(1):1.
doi: 10.1186/s12880-024-01541-9.

Comparative diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and Bayesian network meta-analysis

Ping Yu #  1 , Xujia Zhou #  1   2 , Li Yue  3 , Ling Zhang  1 , Yuan Zhou  4   5 , Fei Jiang  6   7
Affiliations
Comparative Study

Comparative diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and Bayesian network meta-analysis

Ping Yu et al. BMC Med Imaging. .

Abstract

Purpose: We aimed to perform a Bayesian network meta-analysis to assess the comparative diagnostic performance of different imaging modalities in chronic pancreatitis(CP).

Methods: The PubMed, Embase and Cochrane Library databases were searched for relevant publications until March 2024. All studies evaluating the head-to-head diagnostic performance of imaging modalities in CP were included. Bayesian network meta-analysis was performed to compare the sensitivity and specificity between the imaging modalities. The Quality Assessment of Diagnostic Performance Studies (QUADAS-2) tool was used to evaluate the quality of studies.

Results: This meta-analysis incorporated 17 studies. Network meta-analytic results indicated that endoscopic ultrasonography (EUS) achieved the highest surface under the cumulative ranking (SUCRA) value at 0.86 for sensitivity. Conversely, magnetic resonance imaging (MRI) demonstrated best specificity, recording the highest SUCRA value at 0.99. Ultrasonography (US) displayed comparatively lower sensitivity than endoscopic retrograde cholangiopancreatography (ERCP) (relative risk[RR]: 0.83, 95% Confidence Interval[CI]: 0.69-0.99) and EUS (RR: 0.73, 95% CI: 0.57-0.91). MRI outperformed all other imaging modalities in terms of specificity.

Conclusions: It appears that EUS demonstrates higher sensitivity, while MRI exhibits higher specificity in patients with chronic pancreatitis. However, it is crucial to note that our analysis was limited to the diagnostic performance and did not evaluate the cost-effectiveness of these various imaging modalities. Consequently, further extensive studies are needed to assess the benefit-to-risk ratios comprehensively.

Keywords: Chronic pancreatitis; Compare; Diagnostic performance; Imaging modalities; Meta-analysis.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This is a systematic review and meta-analysis, ethics approval and consent to participate are not applicable. Consent for publication: Not applicable. The manuscript does not include the participant’s identification image or other personal or clinical details. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram illustrating the study selection process
Fig. 2
Fig. 2
Risk of bias and applicability concerns of the included studies using the Quality Assessment of Diagnostic Performance Studies QUADAS-2 tool
Fig. 3
Fig. 3
Network diagram of all eligible studies evaluating the sensitivity of seven diagnostic imaging modalities for chronic pancreatitis in the Bayesian network meta-analysis. The node size corresponds to the number of patients, and the line width reflects the number of studies included
Fig. 4
Fig. 4
Network diagram of all eligible studies evaluating the specificity of seven diagnostic imaging modalities for chronic pancreatitis in the Bayesian network meta-analysis. The node size corresponds to the number of patients, and the line width reflects the number of studies included
Fig. 5
Fig. 5
Funnel plot to assess the publication bias for sensitivity in the included studies
Fig. 6
Fig. 6
Funnel plot to assess the publication bias for specificity in the included studies
See this image and copyright information in PMC

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