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Randomized Controlled Trial
. 2025 Jan 2;25(1):1.
doi: 10.1186/s12902-024-01793-0.

Modulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a randomized controlled trail

Masoud Nasiri  1 , Amirabbas Monazzami  2 , Solmaz Alavimilani  3 , Zatollah Asemi  4
Affiliations
Randomized Controlled Trial

Modulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a randomized controlled trail

Masoud Nasiri et al. BMC Endocr Disord. .

Abstract

Purpose: Polycystic ovary syndrome (PCOS) is a frequent disorder among women. Exercise training has been known as an effective treatment for this disorder; however, there is small amount of evidence examining the optimal exercise programs. We evaluated the function of combined (COM) training on metabolic, hormonal parameters, and biomarkers of oxidative stress and inflammation in PCOS patients.

Methods: This randomized controlled clinical trial was conducted on 30 women with PCOS divided (age: 23.8 ± 5.3 years, height:162.8 ± 4.9 cm, weight: 82.4 ± 9.7 kg, body mass index: 30.3 ± 3.9 kg/m2) into two groups to receive COM training intervention (n = 15) or control group (n = 15) for eight weeks. At the baseline and end-of-intervention, metabolic profiles including fasting plasma glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), lipid profiles, testosterone, free androgen index (FAI), sex hormone binding globulin, anti-Müllerian hormone, malondialdehyde, total antioxidant capacity, and high Sensitive-C reactive protein were evaluated.

Results: After eight-week intervention in training group, insulin (P < 0.001), HOMA-IR (P < 0.001), total cholesterol (P < 0.001), LDL-cholesterol (P < 0.001), total testosterone (P < 0.001), AMH ( P = 0.02),MDA (P = 0.04) and FAI (P < 0.001) were significantly decreased, while QUICKI (P = 0.002) was remarkably increased compared with the control group. Moreover, findings showed that there are no significant differences in other variables in the training group compared to the control group.

Conclusions: We concluded that combined training is an effective training protocol (50%-70% 1RM for strength training and 60%-70 THR for endurance training) for treatment of PCOS, although further studies are needed to reach comprehensive data regarding the design of exercise protocols with different intensity and volume for PCOS patients.

Trial registration: Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20130812014333N143) on March 22, 2020. Access at https://en.irct.ir/trial/46295 .

Keywords: Endurance training; Metabolic biomarkers; PCOS; Resistance training.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This research was approved by the Ethics Committee of Kermanshah University of Medical Sciences with the code (IR.kums.REC.1398.1186). The Iranian website of clinical trials registration approved (2020–03-22) the current study with IRCT number: IRCT20130812014333N143, URL: https://en.irct.ir/trial/46295 , and this study was conducted under the Declaration of Helsinki. After being informed of the benefits and risks of research, participants signed written consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Diagram of the progress through the phases of the parallel randomized trial of two groups (enrolment, allocation, follow-up, and data analysis)
Fig. 2
Fig. 2
Androgens and AMH profiles at baseline and after eight-week intervention in patients with PCOS. AMH, Anti-Müllerian Hormone; FAI, Free androgen index; SHBG, Sex hormone binding globulin. * Significant difference with pre-test (p < 0.05). # Significant difference with the changes of the control group (∆) (p < 0.05)
See this image and copyright information in PMC

References

    1. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6–15. 10.1016/j.fertnstert.2016.05.003. - DOI - PubMed
    1. Alur-Gupta S, Chemerinski A, Liu C, et al. Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety. Fertil Steril. 2019;112(5):930-938.e1. 10.1016/j.fertnstert.2019.06.018. - DOI - PMC - PubMed
    1. Kiel IA, Lionett S, Parr EB, Jones H, Røset MAH, Salvesen Ø, Vanky E, Moholdt T. Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open. 2020;10(2):e034733. 10.1136/bmjopen-2019-034733. - DOI - PMC - PubMed
    1. Bijeh N, Hejazi K, Delpasand A. Acute and chronic responses of serum leptin hormone to different intensities of exercise in rats with polycystic ovarian syndrome. Pathobiol Res. 2015;18(1):95–106.
    1. Nowak I, Ciećwież S, Łój B, Brodowski J, Brodowska A. Adiponectin Gene Polymorphism (rs17300539) has no influence on the occurrence of metabolic syndrome in women with polycystic ovary syndrome. Genes (Basel). 2021;12(12):1902. 10.3390/genes12121902. - DOI - PMC - PubMed

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