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Case Reports
. 2025 Jan;28(1):e70038.
doi: 10.1111/1756-185X.70038.

Lethal Gastrointestinal Manifestation and 3D-Reconstructive CT in Systemic Polyarteritis Nodosa (PAN)

Wahinuddin Sulaiman  1   2 , Fahd Adeeb  3   4 , Mahendra Mano  5 , Yeoh Huat Chee  2 , Roslina Suboh  6 , Clarence Ong Teong Oon  7 , Ong Ping Seung  8
Affiliations
Case Reports

Lethal Gastrointestinal Manifestation and 3D-Reconstructive CT in Systemic Polyarteritis Nodosa (PAN)

Wahinuddin Sulaiman et al. Int J Rheum Dis. 2025 Jan.
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
(A) Contrast‐enhanced abdominal CT reveals fluid in small bowel loops, ascending and transverse colon (B) Resected segment of small intestines showing extensive necrotic and gangrenous changes with multiple perforations (C) Reconstructed CT renal angiography demonstrating scattered small hyperdense “dots” along lobar and interlobar arteries (D) 3D‐virtual reconstructive CT angiography revealing large abdominal aorta branches with irregular outlines (E–H): Histopathology of the small intestine and caecum (E, F) Focal vasculitis with lymphocyte infiltration, thrombosed blood vessels, and intimal thickening causing lumen narrowing in medium‐sized vessel (G) Cecal mucosal ulceration with adjacent thickened medium‐sized vessel and vasculitis (H) small bowel transmural necrosis (20× magnification).
See this image and copyright information in PMC

References

    1. Halabi C., Williams E. K., Morshed R. A., et al., “Neurological Manifestations of Polyarteritis Nodosa: A Tour of the Neuroaxis by Case Series,” BMC Neurology 21 (2021): 205. - PMC - PubMed
    1. Karadag O., Bolek E. C., Ayan G., et al., “Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study,” Arthritis & Rhematology 76 (2024): 1120–1129. - PMC - PubMed
    1. Jain N., Shankar B., Mitra S., and Singh Y. P., “Polyarteritis Nodosa: Resolution of Radiological Changes,” Rheumatology (Oxford) 60 (2021): 3481–3482. - PubMed
    1. Scatarige J. C., Urban B. A., Hellmann D. B., and Fishman E. K., “Three‐Dimensional Volume‐Rendering CT Angiography in Vasculitis: Spectrum of Disease and Clinical Utility,” Journal of Computer Assisted Tomography 25 (2001): 598–603. - PubMed

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