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. 2024 Dec 28:16:2387-2398.
doi: 10.2147/IJWH.S493708. eCollection 2024.

Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Wenting Xu  1 , Yanxing Huang  2 , Ping Ji  2 , Jiayu Wang  2 , Jinfen Yu  2 , Li Yang  2
Affiliations

Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Wenting Xu et al. Int J Womens Health. .

Abstract

Objective: Failure to resolve inflammation is a novel feature of angiogenic-dependent diseases such as endometriosis and atherosclerosis.The correlation and causality between endometriosis and coronary heart disease is unclear. Here, we investigated the correlation and causality between endometriosis and coronary heart disease.

Methods: The relevant data was extracted from the NHANES database (Year range: 1999-2006) and analyzed to determine the correlation between endometriosis and coronary heart disease using weighted multivariable logistic regression models. Mendelian randomization analysis was used to assess the causal relationship between endometriosis and coronary heart disease risk.

Results: We evaluated the data obtained from 3943 participants and did not observe any association between endometriosis and coronary heart disease in weighted multivariable logistic regression models (Model 1, OR: 1.85, 95% CI: 0.66-5.15, P: 0.23; Model 2, OR: 0.89, 95% CI: 0.30-2.62, P: 0.82; Model 3, OR: 0.61, 95% CI: 0.19-1.95, P: 0.38). Two-sample Mendelian randomization analysis did not reveal a causal relationship between endometriosis and coronary heart disease (OR: 1.00, 95% CI: 0.94-1.07, P: 0.882).

Conclusion: Our findings did not indicate any association or causal relationship between endometriosis and coronary heart disease.

Keywords: Mendelian randomization; NHANES; coronary heart disease; cross-sectional study; endometriosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart for the selection of participants from the NHANES.
Figure 2
Figure 2
Scatter plot of two-sample MR analysis.
See this image and copyright information in PMC

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