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Review
. 2024 Dec 19:15:1498768.
doi: 10.3389/fphar.2024.1498768. eCollection 2024.

Traditional utilization, botany, phytochemistry, pharmacology, pharmaceutical analysis, processing and application of the seeds of Herpetospermum pedunculosum (Ser.) C.B. Clarke: a comprehensive review

Zhixia Jiang #  1 , Chuang Zhang #  1 , Xinran Yu #  1 , Kaiyi Wang  1 , Zhenqi Sang  1 , Wan Gong  1 , Qiaoyan Zhang  1 , Xiongyu Meng  1 , Lupin Qin  1 , Qiming Zhao  1
Affiliations
Review

Traditional utilization, botany, phytochemistry, pharmacology, pharmaceutical analysis, processing and application of the seeds of Herpetospermum pedunculosum (Ser.) C.B. Clarke: a comprehensive review

Zhixia Jiang et al. Front Pharmacol. .

Abstract

The seed of Herpetospermum pedunculosum (Ser.) C.B. Clarke, known in Chinese as Bo-Leng-Gua-Zi and in Tibetan as Sejimedo, are here abbreviated as H. pedunculosum seeds. Herpetospermum pedunculosum seeds is a traditional Chinese medicine for protecting the liver, clearing heat, and detoxifying. A total of 125 chemical metabolites of H. pedunculosum seeds are found, including lignans, fatty acids, terpenes, coumarins, and others. The pharmacological activities of H. pedunculosum seeds are mainly in hepatoprotective, antioxidant, anti-cancer cells, and anticholestatic effects. In clinical application, it is mainly used in combination with other traditional Chinese medicines to play a key role in treating the liver disease. This paper gives a systematic review of above research aspects, proposes the potential limitations and put forward plausible solutions. Relevant literatures were searched in PubMed, Web of Science and Chinese National Knowledge Infrastructure with Herpetospermum as the key word. A number of studies have shown that H. pedunculosum seeds exert excellent hepatoprotective effects by acting on NF-κB, TGF-β, and Keap1-Nrf2 signaling pathways, which provide a solid base for its clinic application. However, more research is needed to explore the standard cultivation and quality evaluation of H. pedunculosum seeds and systematical structure-activity relationship of its active metabolites.

Keywords: Herpetospermum pedunculosum (Ser.) C.B. Clarke; lignan; liver protection; pharmacological activity; phytochemistry.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flower (A), leaf (B), fruit (C) and seed (D) of Herpetospermum pedunculosum (Ser.) C.B. Clarke.
FIGURE 2
FIGURE 2
Lignan types in Herpetospermum pedunculosum seeds.
FIGURE 3
FIGURE 3
Structures of lignan metabolites in Herpetospermum pedunculosum seeds.
FIGURE 4
FIGURE 4
Structures of fatty acids from Herpetospermum pedunculosum seeds.
FIGURE 5
FIGURE 5
Structures of terpenoids (92–101) and coumarins (102–108).
FIGURE 6
FIGURE 6
Structures of other metabolites from Herpetospermum pedunculosum seeds.
FIGURE 7
FIGURE 7
The mechanism of protective effect of Herpetospermum pedunculosum seeds on liver. (A) NF-κB signaling pathway; (B) TGF-β signaling pathway; (C) Keap1-Nrf2 signaling pathway.
See this image and copyright information in PMC

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References

    1. Asrani S. K., Devarbhavi H., Eaton J., Kamath P. S. (2019). Burden of liver diseases in the world. J. Hepatol. 70 (1), 151–171. 10.1016/j.jhep.2018.09.014 - DOI - PubMed
    1. Bakrim S., Benkhaira N., Bourais I., Benali T., Lee L. H., El Omari N., et al. (2022). Health benefits and pharmacological properties of stigmasterol. Antioxidants (Basel.) 11 (10), 1912. 10.3390/antiox11101912 - DOI - PMC - PubMed
    1. Cang J., De J. (2020). Clinical observation on the treatment of jaundice hepatitis with Tibetan medicine Shiwei heibing tables. J. Med. Pharm. Chin. Minor. 26, 3–5. 10.16041/j.cnki.cn15-1175.2020.05.002 - DOI
    1. Cao W. R., Ge J. Q., Xie X., Fan M. L., Fan X. D., Wang H., et al. (2017). Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats. J. Ethnopharmacol. 198, 139–147. 10.1016/j.jep.2017.01.003 - DOI - PubMed
    1. Chen H. G., Shen B. D., Shen C. Y., Li Z. M., Yuan H. L. (2016). Effects of different processing technology on active ingredients diarrhea and hepatoprotection of Herpetospermum caudigerum . Pharm. J. Chin. People's Lib. Army. 32, 289–292+298.

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