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. 2025 Feb;39(3):e25147.
doi: 10.1002/jcla.25147. Epub 2025 Jan 3.

Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study

Elmutuz H Elssaig  1   2   3 , Eltayib H Ahmed-Abakur  1   2   4 , Tarig M S Alnour  1   2   4 , Mohammed A Alsubai  1   2   3 , Abdalla Eltoum Ali  3 , Mohammad Fahad Ullah  1 , Nizar H Saeedi  1 , Fahad Daefalah Alenzi  5
Affiliations

Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study

Elmutuz H Elssaig et al. J Clin Lab Anal. 2025 Feb.

Abstract

Objectives: To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.

Methods: This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).

Results: The results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively. High frequencies of haplotypes TA and TC were observed in type 2 diabetes patients.

Conclusion: The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.

Keywords: BMI; IGF2BP2; SNPs; T2DM; genetic variants; genomic markers.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Role of IGF2BP2 polymorphisms in type 2 diabetes mellitus.
FIGURE 2
FIGURE 2
Agarose gel electrophoresis of restriction digests of PCR products of (rs4402960) IGF2BP2 gene using Mbo II restriction enzyme on 2% agarose gel. M:100 bp Marker, Sample No 30 and 49 are GG genotype, Sample No 11, 22, 23, 24, 25, and 28 are GT genotype, and Sample No 29 and 22 are TT genotype.
FIGURE 3
FIGURE 3
Agarose gel electrophoresis of restriction digests of PCR products of (rs1470579) IGF2BP2 gene using Fok I restriction enzyme on 2% agarose gel. M:100 bp Marker, Sample No 11 represents CC genotype, Sample No 13 represents AC genotype, and Sample No 16 represents AA genotype.
FIGURE 4
FIGURE 4
Genotypes and frequencies of the IGF2BP2 (rs1470579) polymorphisms in T2DM patients and healthy subjects.
FIGURE 5
FIGURE 5
Genotypes and frequencies of the IGF2BP2 (rs4402960) polymorphisms in T2DM patients and healthy subjects.
See this image and copyright information in PMC

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