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Review
. 2024 Dec 29;27(1):2.
doi: 10.1007/s12017-024-08815-z.

The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer's Disease

Xianbo Zhuang #  1 , Jie Lin #  2   3 , Yamin Song  1 , Ru Ban  1 , Xin Zhao  1 , Zhangyong Xia  4   5   6 , Zheng Wang  7 , Guifeng Zhang  8
Affiliations
Review

The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer's Disease

Xianbo Zhuang et al. Neuromolecular Med. .

Abstract

Alzheimer's disease (AD) is a common progressive neurodegenerative disorder, and the vast majority of cases occur in elderly patients. Recently, the accumulation of Aβ and tau proteins has drawn considerable attention in AD research. This review explores the multifaceted interactions between these proteins and their contribution to the pathological landscape of AD, encompassing synaptic dysfunction, neuroinflammation, and PANoptosis. PANoptosis is a collective term for programmed cell death (PCD) modalities that encompass elements of apoptosis, pyroptosis, and necroptosis. The accumulation of Aβ peptides and tau proteins, along with the immune response in brain cells, may trigger PANoptosis, thus advancing the progression of the disease. Recent advancements in molecular imaging and genetics have provided deeper insights into the interactions between Aβ peptides, tau proteins, and the immune response. The review also discusses the role of mitochondrial dysregulation in AD. The exploration of the interplay between neurodegeneration, immune responses, and cell death offers promising avenues for the development of innovative treatments.

Keywords: Alzheimer’s disease; Amyloid-beta; Inflammation; PANoptosis; Tau protein; Therapeutic strategy.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Ethical Approval and Consent to Participate: This article does not contain any studies with human participants or animals. Consent for Publication: Not applicable.

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