Review on critical factor in monocyte adhesion: Nutrients

Abstract

Endogenous and exogenous factors play a role in endothelial dysfunction. Inflammation, leukocyte adhesion-aggregation, abnormal vascular proliferation, atherosclerosis, and hypertension are among the endogenous factors. Another factor that affects endothelial dysfunction is exogenous factors such as drug treatments, smoking, alcohol, and nutrition. According various studies on nutrition and endothelial function, it is supported that fatty acids, proteins, and phenolic compounds modulate this function. In vitro studies show that nutrients change the adhesion of monocytes to the endothelium. The pathways that play a role in the adhesion process of monocytes are also affected by nutrients. Particularly among these pathways, mTORC1, S6 plaques, monocyte chemotaxis protein, monocyte integrins, monocyte cytokines are transferred to the lesional area selectin protein. In this article, the effects of various nutrients on monocyte adhesion are examined. It explains the changes and possible mechanisms of nutrients such as fatty acids, protein, phenolic compounds, and other dietary components on monocyte adhesion, and examines the relationship between nutrients and monocyte adhesion in our country and allows us to look at our profession from a different perspective. Although not all nutritional elements are included, it is thought that our profession will play a role in taking the first step towards cell studies.

Keywords: CAM molecules; Monocyte adhesion; Monocyte chemotaxis protein; Monocyte cytokines; NF-kB; Nutrients.