. 2025 Jan 5;27(1):5.

doi: 10.1007/s12017-024-08824-y.

Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society

Lisi Flores-Aguilar^#¹, Eric D Hamlett^#², Paula Araya³, Eugenio Barone⁴, Anita Bhattacharyya^{5

6}, Maria Carmona-Iragui^{7

8

9}, Li Chan¹⁰, Brad Christian¹¹, Alberto C S Costa¹², Floriana Costanzo¹³, Laura Del Hoyo Soriano^{7

14}, Mara Dierssen^{15

16}, Evan E Eichler^{17

18}, Elizabeth Fisher¹⁹, Matthew Galbraith²⁰, Sujay Ghosh²¹, Sandra Gimenez²², Faycal Guedj²³, Sandra Guidi²⁴, Maria Florencia Iulita⁷, William Mobley²⁴, Maria Chiara Pelleri²⁵, Marie-Claude Potier²⁶, Karen R Rabin²⁷, Angela Rachubinski³, Anne-Sophie Rebillat²⁸, Eric Rubenstein²⁹, Hannah Saternos³⁰, Lorena Sordo¹, Andre Strydom³¹, Natalia Valle-Tamayo^{7

9}, Katherine A Waugh^{3

20}, Eugene Yu³², Ella Zeldich³³, Jorge Busciglio³⁴, Elizabeth Head³⁵

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
² Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
³ Department of Pediatrics, Section of Developmental Pediatrics, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁴ Department of Biochemical Sciences "A. Rossi-Fanelli, Sapienza University of Rome, Rome, Italy.
⁵ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
⁶ Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
⁸ Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
⁹ Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain.
¹⁰ Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
¹¹ Department of Medical Physics and Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
¹² Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
¹³ Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
¹⁴ MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis Health, 2828 50Th St., Sacramento, CA, USA.
¹⁵ Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
¹⁶ Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
¹⁷ Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
¹⁸ Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
¹⁹ Department of Neuromuscular Diseases, LonDownS: London Down Syndrome Consortium, Queen Square Institute of Neurology, University College London, London, UK.
²⁰ Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
²¹ Cytogenetics and Genomics and Down Syndrome Research Unit, Department of Zoology, University of Calcutta, Kolkata, India.
²² Multidisciplinary Sleep Unit, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
²³ Section On Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
²⁴ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
²⁵ Department of Biomedical and Neuromotor Sciences, Physiology Building, University of Bologna, Bologna, Italy.
²⁶ Institut du Cerveau-Paris Brain Institute-ICM, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié Salpêtrière, Sorbonne Université, Paris, France.
²⁷ Division of Pediatric Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
²⁸ Institut Jérôme Lejeune, Paris, France.
²⁹ Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
³⁰ Department of Neurosurgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³¹ Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
³² The Children's Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
³³ Department of Anatomy and Neurobiology, Boston University, Boston, MA, USA.
³⁴ Neurobiology and Behavior School of Biological Sciences, University of California, Irvine, CA, USA.
³⁵ Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. heade@uci.edu.

^# Contributed equally.

PMID: 39756004
PMCID: PMC11700910
DOI: 10.1007/s12017-024-08824-y

Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society

Lisi Flores-Aguilar et al. Neuromolecular Med. 2025.

. 2025 Jan 5;27(1):5.

doi: 10.1007/s12017-024-08824-y.

Authors

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
² Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
³ Department of Pediatrics, Section of Developmental Pediatrics, Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁴ Department of Biochemical Sciences "A. Rossi-Fanelli, Sapienza University of Rome, Rome, Italy.
⁵ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
⁶ Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
⁸ Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
⁹ Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain.
¹⁰ Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
¹¹ Department of Medical Physics and Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
¹² Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
¹³ Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
¹⁴ MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis Health, 2828 50Th St., Sacramento, CA, USA.
¹⁵ Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
¹⁶ Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
¹⁷ Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
¹⁸ Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
¹⁹ Department of Neuromuscular Diseases, LonDownS: London Down Syndrome Consortium, Queen Square Institute of Neurology, University College London, London, UK.
²⁰ Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
²¹ Cytogenetics and Genomics and Down Syndrome Research Unit, Department of Zoology, University of Calcutta, Kolkata, India.
²² Multidisciplinary Sleep Unit, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
²³ Section On Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
²⁴ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
²⁵ Department of Biomedical and Neuromotor Sciences, Physiology Building, University of Bologna, Bologna, Italy.
²⁶ Institut du Cerveau-Paris Brain Institute-ICM, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié Salpêtrière, Sorbonne Université, Paris, France.
²⁷ Division of Pediatric Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
²⁸ Institut Jérôme Lejeune, Paris, France.
²⁹ Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
³⁰ Department of Neurosurgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³¹ Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
³² The Children's Guild Foundation Down Syndrome Research Program, Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
³³ Department of Anatomy and Neurobiology, Boston University, Boston, MA, USA.
³⁴ Neurobiology and Behavior School of Biological Sciences, University of California, Irvine, CA, USA.
³⁵ Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. heade@uci.edu.

^# Contributed equally.

PMID: 39756004
PMCID: PMC11700910
DOI: 10.1007/s12017-024-08824-y

Abstract

Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 2014, unites a worldwide community dedicated to understanding the impact of T21 on biological systems and improving the quality of life of people with DS across the lifespan. T21RS hosts an international conference every two years to support collaboration, dissemination, and information sharing for this goal. In 2022, T21RS hosted an international conference in Long Beach, California, from June 9 to 12. The conference, attended by 483 people including scientists, families, self-advocates, and industry representatives from 17 countries, was a dynamic and interactive meeting that shared discoveries from international research teams. This summary highlights the scientific discoveries shared at the 4th T21RS meeting with the Imagine, Discover, Inspire theme.

Keywords: Biomarkers; Clinical research; Conference proceedings; Down syndrome; Intellectual disability; Preclinical research.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interests: E.E.E. is a member of the scientific advisory board of Variant Bio, Inc. The other authors have no conflicts of interest to declare.

Figures

**Fig. 1**
Topics covered at the T21RS Meeting

**Fig. 2**
Countries represented by attendees at the T21RS Meeting

See this image and copyright information in PMC

References

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Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society

Affiliations

Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society

Authors

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

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Medical