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Review
. 2025 Mar:127:111584.
doi: 10.1016/j.cellsig.2024.111584. Epub 2025 Jan 3.

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

John Y Kwon  1 , Renzo E Vera  2 , Martin E Fernandez-Zapico  3
Affiliations
Review

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

John Y Kwon et al. Cell Signal. 2025 Mar.

Abstract

The tumor microenvironment (TME) has been linked with the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer. A central component of the TME are cancer-associated fibroblasts (CAFs), which can either suppress or promote tumor growth in a context-dependent manner. In this review, we will discuss the multi-faceted roles of CAFs in tumor-stroma interactions influencing cancer initiation, progression and therapeutic response.

Keywords: Cancer associated fibroblasts; PDAC; Stroma; Tumor microenvironment.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict with the manuscript.

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