AIDS-related mycoses: advances, challenges, and future directions

Rachael Dangarembizi¹, Jennifer Claire Hoving², David R Boulware³, Arnaldo Lopes Colombo⁴, Nelesh P Govender⁵, Rita Oladele⁶, Vu Quoc Dat⁷, Ilan S Schwartz⁸, Gordon D Brown⁹

Affiliations

¹ Department of Human Biology, Neuroscience Institute, University of Cape Town, Cape Town, South Africa; CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: rachael.dangarembizi@uct.ac.za.
² CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
³ Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
⁴ Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil; Sao Paulo Institute of Antimicrobial Resistance (ARIES), Sao Paulo, Brazil.
⁵ Mycology Division, Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infection and Immunity, City-St George's University London, London, UK; Medical Research Centre for Medical Mycology, University of Exeter, Exeter, UK.
⁶ Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
⁷ Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam.
⁸ Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.
⁹ CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Medical Research Centre for Medical Mycology, University of Exeter, Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter, UK.

PMID: 39757034
DOI: 10.1016/j.tim.2024.12.004

AIDS-related mycoses: advances, challenges, and future directions

Rachael Dangarembizi et al. Trends Microbiol. 2025 Feb.

. 2025 Feb;33(2):141-144.

doi: 10.1016/j.tim.2024.12.004. Epub 2025 Jan 4.

Authors

Rachael Dangarembizi¹, Jennifer Claire Hoving², David R Boulware³, Arnaldo Lopes Colombo⁴, Nelesh P Govender⁵, Rita Oladele⁶, Vu Quoc Dat⁷, Ilan S Schwartz⁸, Gordon D Brown⁹

Affiliations

¹ Department of Human Biology, Neuroscience Institute, University of Cape Town, Cape Town, South Africa; CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address: rachael.dangarembizi@uct.ac.za.
² CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
³ Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
⁴ Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil; Sao Paulo Institute of Antimicrobial Resistance (ARIES), Sao Paulo, Brazil.
⁵ Mycology Division, Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Institute of Infection and Immunity, City-St George's University London, London, UK; Medical Research Centre for Medical Mycology, University of Exeter, Exeter, UK.
⁶ Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
⁷ Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam.
⁸ Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.
⁹ CMM AFRICA Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Medical Research Centre for Medical Mycology, University of Exeter, Exeter, Department of Biosciences, Faculty of Health and Life Sciences, Exeter, UK.

PMID: 39757034
DOI: 10.1016/j.tim.2024.12.004

Abstract

Fungal infections are a major contributor to mortality for people with HIV/AIDS. Recently, researchers, clinicians, industry experts, and policymakers convened for the triennial AIDS-Related Mycoses Meeting to address critical gaps in the management of AIDS-related mycoses. Delegates highlighted several scientifically driven milestones that have significantly reduced fungal-related deaths, and the need to address outstanding challenges in diagnosis, treatment, and research.

Keywords: HIV/AIDS; antifungal immunity; fungal infections; mycoses; opportunistic infections.

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Conflict of interest statement

Declaration of interests A.L.C. has previously received Educational Grants from Mundipharma, Sandoz, Gilead, Knight-United Medical, Pfizer, and a research grant from Knight-United Medical. The remaining authors have no interests to declare.

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AIDS-related mycoses: advances, challenges, and future directions

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AIDS-related mycoses: advances, challenges, and future directions

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