Review
doi: 10.1016/j.molmed.2024.12.007.
Epub 2025 Jan 4.
Gut microbiota and bilirubin metabolism: unveiling new pathways in health and disease
Affiliations
- PMID: 39757046
- DOI: 10.1016/j.molmed.2024.12.007
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Review
Gut microbiota and bilirubin metabolism: unveiling new pathways in health and disease
Trends Mol Med.
2025 Jul.
Abstract
Bilirubin reductase (BilR), a gut microbiota-derived enzyme that reduces bilirubin to urobilinogen, was recently identified. Given the role of bilirubin in preventing modern diseases, understanding the link between the gut microbiota and health via modulation of bilirubin metabolism marks a major advance in medical research and potential treatments.
Keywords: bilirubin; gut microbiota; intestinal metabolism; urobilinogen; urobilinoids.
Copyright © 2024 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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