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Case Reports
. 2024 Dec 11;12(1):100154.
doi: 10.1016/j.acpath.2024.100154. eCollection 2025 Jan-Mar.

Educational Case: Psoriasis

Ryan C Saal  1 , Abby S Van Voorhees  2 , Richard M Conran  3
Affiliations
Case Reports

Educational Case: Psoriasis

Ryan C Saal et al. Acad Pathol. .
No abstract available

Keywords: Chronic inflammatory dermatoses; Immune-related disorders of the skin; Organ system pathology; Pathology competencies; Psoriasis; Skin.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Well-demarcated plaques with silvery-white scale located on the middle and lower back. Image used with permission from VisualDx (www.visualdx.com).
Fig. 2
Fig. 2
A. Regular acanthosis with confluent parakeratosis and elongation of rete ridges. (H&E, intermediate magnification). B. Parakeratosis and acanthosis with neutrophils present in the stratum corneum (Munro microabscess) are identified by the arrow. (H&E, intermediate magnification).
Fig. 3
Fig. 3
An overview of the pathogenesis of psoriasis. Trauma, stress, and infection damage keratinocytes, resulting in the release of antimicrobial peptides (e.g. LL37, S100 proteins, cathelicidin). These peptides activate plasmacytoid dendritic cells, responsible for secreting TNF-α, IL-12, and IL-23. CD8 cells, Th17 cells, and other lymphocytes are then activated, and release cytokines such as TNF-α, IL-17, and IL-22. These cytokines are responsible for epidermal hyperplasia and skin barrier dysfunction. Reproduced under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) from Figure 5 in Psoriasis Pathogenesis and Treatment by Rendon A and Schakel K in the International Journal of Molecular Sciences 2019 20 (6): 1475. doi:10.3390/ijms20061475.
See this image and copyright information in PMC

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