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. 2024 Dec 20:16:1505645.
doi: 10.3389/fnagi.2024.1505645. eCollection 2024.

Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study

Kai Wu  1 , Liang Pang  1 , Pingping Su  1 , Cunxian Lv  1
Affiliations

Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study

Kai Wu et al. Front Aging Neurosci. .

Abstract

Objective: Metal implants play a vital role in orthopedic treatment and are widely used in fracture repair, joint replacement and spinal surgery. Although these implants often contain key elements such as chromium (Cr), their potential health effects, particularly their association with stroke risk, have not been fully elucidated. This study aimed to evaluate the association between metallic implants and stroke.

Methods: Using data from the 2015 to 2023 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional analysis of 12,337 US adults, in which 3,699 participants reported having metal implants and 8,638 without. Implant-like.

Results: Through logistic regression analysis, we revealed a significant positive association between metallic implants and stroke risk (adjusted OR = 1.458, 95%CI (1.130, 1.881), p = 0.004). Further stratified analysis found that this positive association was more significant among older and less physically active participants.

Conclusion: Findings suggest that metallic implants may be associated with an increased risk of stroke, but given the inherent limitations of cross-sectional studies, this study cannot establish causality.

Keywords: NHANES; cross-sectional study; metal implants; risk factors; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of participant selection.
See this image and copyright information in PMC

Comment in

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