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Review
. 2024 Dec 5;16(12):e75138.
doi: 10.7759/cureus.75138. eCollection 2024 Dec.

Cortical Laminar Bone Membrane: Transforming Regenerative Approaches in Dentistry

Rohida Nehal  1 , Ayush Agrawal  1 , Vinayak Thorat  1 , Sanpreet S Sachdev  2
Affiliations
Review

Cortical Laminar Bone Membrane: Transforming Regenerative Approaches in Dentistry

Rohida Nehal et al. Cureus. .

Abstract

Cortical laminar bone membrane (CLBM) is well known for its extraordinary mechanical properties, biocompatibility, and osteoconductive potential, and thus, it has been revealed as a revolutionary biomaterial in periodontal and alveolar bone regeneration. CLBM offers a superior alternative to traditional barrier membranes used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). CLBM represents a significant advancement in managing complex defects by overcoming common limitations such as premature degradation and inadequate soft tissue support. The review combines insights from current research to evaluate the properties, biological mechanisms, and clinical applications of CLBM, alongside its comparative advantages and limitations.

Keywords: acceleration of bone formation; alveolar bone loss; alveolar bone resorption; generalized periodontitis; osteogenesis; osteoinduction.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Biological mechanisms of action of cortical laminar bone membrane
BMP: bone morphogenic protein, MSCs: mesenchymal stem cells, VEGF: vascular endothelial bone factor Image credit: Nehal Rohida, Ayush Agrawal
See this image and copyright information in PMC

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