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. 2025 Jan;15(1):29.
doi: 10.1007/s13205-024-04182-5. Epub 2025 Jan 2.

Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway

Gaofeng Qin  1 , Weijuan Cui  2 , Rongqiang Song  1
Affiliations

Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway

Gaofeng Qin et al. 3 Biotech. 2025 Jan.

Abstract

The etiology and pathogenesis of Alzheimer's disease (AD) are complex, and currently, no comprehensive treatment measures exist. In this study, we initially utilized ultra-high-performance liquid chromatography with quadrupole orbitrap mass spectrometry (UHPLC-QE-MS) to profile the bioactive constituents of SZLOL present in the bloodstream. Subsequent Y-maze experimental data demonstrated that SZLOL could ameliorate short-term memory deficits in APP/PS1 mice. Furthermore, micro-positron emission tomography (Micro-PET) experiments revealed that SZLOL enhanced glucose metabolism in the cerebral cortex of the mice. To model AD in vitro, we utilized Aβ42-induced SH-SY5Y cells and assessed the effects of SZLOL-containing serum on cell growth and migration using immunofluorescence and wound-healing assays. Both in vivo and in vitro Western blot analyses indicated that SZLOL and SZLOL-containing serum were capable of activating the PI3K/Akt signaling pathway, which modulates the expression of inflammatory mediators. In future studies, we will validate our findings in more animal and cell models.

Keywords: Alzheimer’s disease; Autophagy; Neuroinflammation; PI3K/Akt pathway; Shen Zhi Ling oral liquid.

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Conflict of interest statement

Conflict of interestThe authors declare no competing interests.

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