Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 20:14:1476603.
doi: 10.3389/fcimb.2024.1476603. eCollection 2024.

Longitudinal ozone exposure and SARS-CoV-2 infection in late pregnancy: a retrospective cohort study

Lin Zhang  1   2 , Jiaqi Tian  1   2 , Shuyin Duan  3
Affiliations

Longitudinal ozone exposure and SARS-CoV-2 infection in late pregnancy: a retrospective cohort study

Lin Zhang et al. Front Cell Infect Microbiol. .

Abstract

Background: Atmospheric ozone is a common air pollutant with known impacts on maternal and fetal health. However, the relationship between gestational ozone exposure and susceptibility to respirovirus infection remains unclear. This study aims to assess the association between longitudinal ozone exposure during pregnancy and COVID-19 risk in late gestation.

Methods: This retrospective cohort study included 600 pregnant women (300 infected with SARS-CoV-2 and 300 uninfected) who delivered at one hospital in Jinan, China from November 2022 to January 2023. Individual ozone exposure levels throughout gestation were estimated based on local ambient monitoring data. Logistic regression models were constructed to examine the association between gestational ozone exposure and COVID-19 status in late pregnancy, adjusting for demographic and clinical variables.

Results: In Jinan, ozone levels increased by 1.85 ppb annually and peaked between April and October, corresponding to winds from the south and southwest. Higher ozone exposure over pregnancy was associated with lower odds of SARS-CoV-2 infection in late gestation (OR per IQR increase = 0.60, 95% CI: 0.40-0.90). Compared to the lowest quartile (reference), the highest ozone quartile corresponded to a 99% decreased infection risk (OR = 0.01, 95% CI: 0.00-0.03). Increased maternal age and pre-pregnancy BMI were associated with higher COVID-19 risk.

Conclusions: Longitudinal ozone exposure during gestation may be protective against SARS-CoV-2 infection in late pregnancy. Further studies are needed to confirm this finding and elucidate underlying mechanisms. These results highlight the potential importance of environmental exposures in COVID-19 susceptibility.

Keywords: SARS-CoV-2 infection; environmental epidemiology; gestational ozone exposure; pregnancy outcomes; viral susceptibility.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Characterization of atmospheric ozone in Jinan, China between 2015 and 2023. (A) Theil-Sen trend analysis of ozone levels from 2015 to 2023. (B) Monthly ozone variations for 2022 and 2023, with wind directions indicated by green arrows. (C) Hourly ozone variations throughout the study period. (D–F) Polar plots illustrating ozone level variations (D), clustering analysis (E), and differences between 2021 and 2022 (F).
Figure 2
Figure 2
Multivariate logistic regression analysis predicting SARS-CoV-2 infection with continuous ozone.
Figure 3
Figure 3
Multivariate logistic regression analysis predicting SARS-CoV-2 infection with interquartile ozone.
See this image and copyright information in PMC

References

    1. Adrielle dos Santos L., Filho P. G., de G., Silva A. M. F., Santos J. V. G., Santos D. S., et al. . (2021). Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. J. Infect. 82, 399–406. doi: 10.1016/j.jinf.2021.01.020 - DOI - PMC - PubMed
    1. Bayarri B., Cruz-Alcalde A., López-Vinent N., Micó M. M., Sans C. (2021). Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses. J. Hazard. Mater. 415, 125658. doi: 10.1016/j.jhazmat.2021.125658 - DOI - PMC - PubMed
    1. Blanco A., Ojembarrena F., de B., Clavo B., Negro C. (2021). Ozone potential to fight against SAR-COV-2 pandemic: facts and research needs. Environ. Sci. pollut. R. 28, 16517–16531. doi: 10.1007/s11356-020-12036-9 - DOI - PMC - PubMed
    1. Cervantes M. A. V., Martinez J. A. V., García L. D. G., Ortega O. L., Romero H. A., Estrada A. M., et al. . (2023). Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells. Virus Genes 59, 781–785. doi: 10.1007/s11262-023-02014-x - DOI - PubMed
    1. Chen J., Guo L., Liu H., Jin L., Meng W., Fang J., et al. . (2023). Modification effects of ambient temperature on associations of ambient ozone exposure before and during pregnancy with adverse birth outcomes: A multicity study in China. Environ. Int. 172, 107791. doi: 10.1016/j.envint.2023.107791 - DOI - PubMed

LinkOut - more resources