Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan 6;317(1):179.
doi: 10.1007/s00403-024-03741-3.

Combinational treatment approaches for acanthosis nigricans: a review

Aishwarya Gangwar  1 , Vipin Sharma  2 , Rohit Sharma  2
Affiliations
Review

Combinational treatment approaches for acanthosis nigricans: a review

Aishwarya Gangwar et al. Arch Dermatol Res. .

Abstract

Acanthosis Nigricans is characterised by hyperpigmented, hyperkeratotic, dark, rough patches or plaques distributed in intertriginous areas. Hyperkeratosis is the main concern that leads to the darkening of the skin. Numerous treatment options are available. Topical retinoids are first-line therapy given to treat hyperpigmented plaques where the limiting factor is skin irritation. To combat this, combinational therapies have come into existence and are being used. In this state-of-the-art review, the authors summarize the pathophysiology of AN, provide an update on combinational treatment strategies, and describe the other therapeutic options that have been advantageous so far in the literature for this disease. The paper aims to review the use of retinoids as a first line treatment option as well as combinational approaches to treat acanthosis nigricans skin condition.

Keywords: Acanthosis nigricans; Chemical peels; Combinational therapy; Topical retinoids.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Similar articles

See all similar articles

References

    1. Schwartz RA (Jul. 1994) Acanthosis nigricans. J Am Acad Dermatol 31(1):1–19. https://doi.org/10.1016/S0190-9622(94)70128-8
    1. Phiske M (2014) An approach to acanthosis nigricans. Indian Dermatol Online J 5(3):239. https://doi.org/10.4103/2229-5178.137765 - DOI - PubMed - PMC
    1. Judge MR, McLean WHI, Munro CS (2010) Disorders of Keratinization. in Rook’s Textbook of Dermatology. Wiley, pp 1–122. https://doi.org/10.1002/9781444317633.ch19
    1. Das A et al (2014) Unilateral nevoid acanthosis nigricans: uncommon variant of a common disease. Indian Dermatol Online J 5(5):40. https://doi.org/10.4103/2229-5178.144529 - DOI
    1. Anand V, Das A, Kumar P, Kumar R, Hassan S (2014) Acral acanthosis nigricans (acral acanthotic anomaly). Indian Dermatol Online J 5(6):140. https://doi.org/10.4103/2229-5178.146201 - DOI

MeSH terms

LinkOut - more resources