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. 2025 Dec;17(1):2447821.
doi: 10.1080/19490976.2024.2447821. Epub 2024 Dec 30.

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content

Baohua Luo  1   2 , Qingling An  1 , Jingyu Lei  3 , Dengxu Tan  1 , Xiaoqiu Liu  4 , Hui Li  3 , Yong Zhao  1 , Jing Qin  1 , Caiqin Zhang  1 , Yongbin Zhang  5 , Changhong Shi  1
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Free article

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content

Baohua Luo et al. Gut Microbes. 2025 Dec.
Free article

Abstract

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

Keywords: Resveratrol; immune checkpoint inhibitors; intestinal microbiota; pancreatic cancer; prostaglandin D2.

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