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Review
. 2025 Jan 7;74(1):1.
doi: 10.1007/s00011-024-01972-8.

Targeting mitochondrial function as a potential therapeutic approach for allergic asthma

Daichi Chen  1 , Wanhua Wu  1 , Jianing Li  1 , Xueqin Huang  1 , Su Chen  2 , TingTing Zheng  1 , Gonghua Huang  1 , Suidong Ouyang  3   4
Affiliations
Review

Targeting mitochondrial function as a potential therapeutic approach for allergic asthma

Daichi Chen et al. Inflamm Res. .

Abstract

Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, excessive mucus secretion, and airway remodeling, with increasing mortality and incidence globally. The pathogenesis of allergic asthma is influenced by various factors including genetics, environment, and immune responses, making it complex and diverse. Recent studies have found that various cellular functions of mitochondria such as calcium regulation, adenosine triphosphate production, changes in redox potential, and free radical scavenging, are involved in regulating the pathogenesis of asthma. This review explores the involvement of mitochondrial functional changes in the pathogenesis of asthma, and investigate the potential of targeting cellular mitochondria as a therapeutic approach for asthma. Those insights can provide a novel theoretical foundations and treatment strategies for understanding and preventing asthma.

Keywords: Allergic asthma; Mitochondrial function; Pathogenesis; Therapeutic targets.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no conflict of interest.

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