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. 2024 Dec;178(2):202-208.
doi: 10.1007/s10517-025-06307-z. Epub 2025 Jan 7.

Complex of Angiotensin II with Modified Low-Density Lipoproteins: Behavioral and Hemodynamic Effects in Rats

S M Tolpygo  1 , B B Shoibonov  2 , T S Zamolodchikova  2 , A V Kotov  2
Affiliations

Complex of Angiotensin II with Modified Low-Density Lipoproteins: Behavioral and Hemodynamic Effects in Rats

S M Tolpygo et al. Bull Exp Biol Med. 2024 Dec.

Abstract

Endogenous multiple modified LDL (mLDL) and the renin-angiotensin system play a significant role in the development of atherosclerosis. It has been found that by behavioral and hemodynamic parameters the physiological activity of angiotensin II (Ang II) in combination with mLDL is considerably modified due to weakening of its diuretic effect and the inversion of hypertensive and tachyarrhythmic effects. Atherosclerosis is a long-term pathological process, so a single administration of artificially synthesized Ang I-mLDL complexes can be considered a model of the first contact of the body with pathogenic factors. We believe that angiotensin complexes with mLDL participate in adaptive and compensatory mechanisms at the initial stages of atherosclerosis and later contribute to its progression.

Keywords: angiotensin II; atherosclerosis modeling; drinking behavior; hemodynamics; modified low-density lipoproteins.

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