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Comment
. 2025 Jan 6;29(1):7.
doi: 10.1186/s13054-024-05240-3.

The elusive concept of appropriate antibiotic for septic patients when a pathogen is not detected by standard culture methods

Alberto Enrico Maraolo  1 , Rita Murri  2 , Danilo Buonsenso  3   4 , Massimo Fantoni  2 , Maurizio Sanguinetti  5
Affiliations
Comment

The elusive concept of appropriate antibiotic for septic patients when a pathogen is not detected by standard culture methods

Alberto Enrico Maraolo et al. Crit Care. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors do not report any competing interest.

Figures

Fig. 1
Fig. 1
Challenges and solutions in culture-negative sepsis management
See this image and copyright information in PMC

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References

    1. Chang Y, Oh JH, Oh DK, Lee SY, Hyun DG, Park MH, Lim CM, Korean Sepsis Alliance (KSA) investigators. Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study. Crit Care. 2024;28(1):385. - PMC - PubMed
    1. Pham A, Cummings M, Lindeman C, Drummond N, Williamson T. Recognizing misclassification bias in research and medical practice. Fam Pract. 2019;36(6):804–7. - PubMed
    1. Liborio MP, Harris PNA, Ravi C, Irwin AD. Getting up to speed: rapid pathogen and antimicrobial resistance diagnostics in sepsis. Microorganisms. 2024;12(9):1824. - PMC - PubMed
    1. Michael Miller J, Binnicker MJ, Campbell S, Carroll KC, Chapin KC, Gonzalez MD, Harrington A, Jerris RC, Kehl SC, Leal SM, Patel R, Pritt BS, Richter SS, Robinson-Dunn B, Snyder JW, Telford S, Theel ES, Thomson RB, Weinstein MP, Yao JD. Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the infectious diseases society of America (IDSA) and the American Society for microbiology (ASM). Clinic Infect Diseases. 2024. 10.1093/cid/ciae104. - PubMed
    1. Rello J, Allam C, Ruiz-Spinelli A, Jarraud S. Severe Legionnaires’ disease. Ann Intensive Care. 2024. 10.1186/s13613-024-01252-y. - PMC - PubMed

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