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. 1985;65(3-4):318-21.
doi: 10.1007/BF00687015.

A rabbit model of intracerebral hematoma

H H Kaufman, J L Pruessner, D P Bernstein, A Borit, P T Ostrow, D L Cahall

A rabbit model of intracerebral hematoma

H H Kaufman et al. Acta Neuropathol. 1985.

Abstract

The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%-5% of their brain volume with a high proportion of clots. Fluorescein can be used to study the blood-brain barrier, and gravimetry to study edema. Others have found that injection of a paraffin/oil mixture can be employed for a control model. Refinement of the fluorescein technique, development of a primate model, and directions for future research are suggested.

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References

    1. J Neurol Neurosurg Psychiatry. 1968 Dec;31(6):616-20 - PubMed
    1. J Neurosurg. 1982 Jul;57(1):99-107 - PubMed
    1. Acta Neuropathol. 1981;54(1):55-61 - PubMed
    1. Adv Neurol. 1980;28:15-26 - PubMed
    1. J Neurosurg. 1978 Oct;49(4):530-7 - PubMed

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