Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
[Preprint]. 2024 Dec 17:rs.3.rs-5443965.
doi: 10.21203/rs.3.rs-5443965/v1.

Impact of Differentiated Service Delivery Models on Quality of Life among People living with HIV in Uganda - A Quasi-Experimental Study

Affiliations

Impact of Differentiated Service Delivery Models on Quality of Life among People living with HIV in Uganda - A Quasi-Experimental Study

Benson Nasasira et al. Res Sq. .

Update in

Abstract

Background: Differentiated service delivery (DSD) models in resource-limited settings have reduced strain on health services and improved client experience, retention and viral suppression, but little is known about the impact of HIV DSD models on quality of life (QoL), which is essential for optimizing person-centered care. This study assessed the impact of DSD models on QoL, loss to follow-up (LTFU), and mortality among persons living with HIV (PLHIV) on ART over time at a large urban HIV clinic in Uganda.

Methods: We analyzed records of 1,000 PLHIV who had been on ART for 10 years and followed up for eight years, starting in 2014 or 2015 at the Infectious Diseases Institute clinic in Kampala, Uganda. The primary outcome, QoL, was assessed using an adapted Medical Outcomes Study (MOS-HIV) tool. Secondary outcomes included sustained viral suppression (< 200 copies/mL), all-cause mortality, and loss to follow-up or LTFU (missing clinic visits for ≥ 3 months). Outcomes were compared across three DSD models-fast-track drug refill (FTDR), facility-based groups (FBG), and a composite model combining FTDR and FBG against the facility-based individual management (FBIM), the standard of care (SOC). Inverse probability treatment weighting was used to achieve comparability in measured covariates across the DSD models followed by mixed effects modeling. Robustness of results was checked using G-computation analysis.

Results: Of 1,000 records for PLHIV, 980 were analyzed. 62% were female and 95% virally suppressed at baseline. After eight years of follow-up, participants on DSD models had higher QoL (90.4% vs 89.1%; weighted mean ratio 3.66, 95% CI 2.10-6.37, p-value < 0.001), better sustained viral suppression, lower mortality, and reduced LTFU rates compared to SOC.

Conclusion: These findings support the broader adoption of DSD models in delivering ART across HIV programs to enhance the QoL and clinical outcomes among PLHIV.

Keywords: Antiretroviral Therapy; Delivery of Health Care; HIV Infections; Health Services Accessibility; Quality of Life.

PubMed Disclaimer

Conflict of interest statement

Additional Declarations: No competing interests reported. Competing interests All authors declare no competing interests

Figures

Figure 1
Figure 1. Mean QoL score profile over time by the DSD model categories
QoL scores are at 100-percentage points scale. The Y-axis is truncated at 70% for clear visibility of the difference between groups. The dashed black vertical line denotes the 2nd wave 2021 COVID-19 lockdown in Uganda.

Similar articles

References

    1. Holzemer WL, Human S, Arudo J, Rosa ME, Hamilton MJ, Corless I, Robinson L, Nicholas PK, Wantland DJ, Moezzi S, Willard S. Exploring HIV stigma and quality of life for persons living with HIV infection. J Assoc Nurses AIDS Care. 2009;20(3):161–8. - PubMed
    1. WHO. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. Geneva, Switzerland: WHO; 2016. - PubMed
    1. IAS. Differentiated care for HIV: a decision framework for antiretroviral therapy delivery. 2016.
    1. Dommaraju S, Hagey J, Odeny TA, Okaka S, Kadima J, Bukusi EA, et al. Preferences of people living with HIV for differentiated care models in Kenya: A discrete choice experiment. PLoS ONE. 2021;16(8):e0255650. 10.1371/journal.pone.0255650. - DOI - PMC - PubMed
    1. Zakumumpa H, Makobu K, Ntawiha W, Maniple E. A mixed-methods evaluation of the uptake of novel differentiated art delivery models in a national sample of health facilities in uganda. PLoS ONE [Electronic Resource]. 2021;16(7):e0254214. 10.1371/journal.pone.0254214. - DOI - PMC - PubMed

Publication types

LinkOut - more resources