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. 2025 Jan 6;13(1):e70074.
doi: 10.1002/ccr3.70074. eCollection 2025 Jan.

Premature Constriction of Fetal Ductus Arteriosus Caused by Sertraline in a Pregnant Woman: A Case Report

Alireza Golbabaei  1 , Elham Sadat Alavi Moghaddam  2 , Hooman Mohammad Talebi  3
Affiliations

Premature Constriction of Fetal Ductus Arteriosus Caused by Sertraline in a Pregnant Woman: A Case Report

Alireza Golbabaei et al. Clin Case Rep. .

Abstract

Fetal ductus arteriosus was treated in a 39-year-old pregnant woman in the 33rd week After psychiatric consultation and discontinuation of sertraline which underscores the association of sertraline with premature ductus arteriosus constriction.

Keywords: case report; ductus arteriosus; pregnancy; pregnant woman; sertraline.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The four‐chamber view of the fetal heart demonstrates right ventricular enlargement (RVE) with a notable size discrepancy between the right ventricle (RV) and left ventricle (LV).
FIGURE 2
FIGURE 2
Axial imaging of the cardiac vessels reveals an S‐shaped ductus arteriosus. Notable stenosis is observed at two critical sites: the connection between the pulmonary artery (P) and the ductus arteriosus (DA) (indicated by the yellow arrow) and the junction of the ductus arteriosus with the descending aorta (DAO) (indicated by the red arrow).
FIGURE 3
FIGURE 3
The four‐chamber view with color Doppler imaging demonstrates flow acceleration, evidenced by aliasing.
FIGURE 4
FIGURE 4
Spectral Doppler interrogation at the stenotic segment of the ductus arteriosus reveals elevated peak flow velocity, consistent with hemodynamic narrowing.
FIGURE 5
FIGURE 5
Axial fetal ultrasound demonstrates normalization of right ventricular size and resolution of the previously noted size discrepancy between the right ventricle (RV) and left ventricle (LV), with reversal of the disproportion.
FIGURE 6
FIGURE 6
Spectral Doppler evaluation of the ductus arteriosus demonstrates decreased flow velocity, indicative of a significant reduction in stenosis severity.
See this image and copyright information in PMC

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References

    1. Pugnaloni F., Doni D., Lucente M., Fiocchi S., and Capolupo I., “Ductus Arteriosus in Fetal and Perinatal Life,” Journal of Cardiovascular Development and Disease 11, no. 4 (2024): 1–5. - PMC - PubMed
    1. Braverman A. C. and Beardslee M. A., “CHAPTER 11 ‐ The Bicuspid Aortic Valve,” In Valvular Heart Disease: A Companion to Braunwald's Heart Disease, eds. Otto C. M. and Bonow R. O. 3 ed., (Philadelphia: W.B. Saunders, 2009), 169–186.
    1. Dice J. E. and Bhatia J., “Patent Ductus Arteriosus: An Overview,” Journal of Pediatric Pharmacology and Therapeutics : JPPT : The Official Journal of PPAG 12, no. 3 (2007): 138–146. - PMC - PubMed
    1. Pishgoo B., Saburi A., and Khosravi A., “A Rare Presentation of Patent Ductus Arteriosus in an Adult Patient With Normal Pulmonary Hypertension and Limb Edema,” ARYA Atherosclerosis 10, no. 5 (2014): 273–275. - PMC - PubMed
    1. Wang S., Yang L., Wang L., Gao L., Xu B., and Xiong Y., “Selective Serotonin Reuptake Inhibitors (SSRIs) and the Risk of Congenital Heart Defects: A Meta‐Analysis of Prospective Cohort Studies,” Journal of the American Heart Association 4, no. 5 (2015): e001681. - PMC - PubMed

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