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. 2024 Dec 30:2024:3616532.
doi: 10.1155/ah/3616532. eCollection 2024.

Comparison of Band Percentage vs Immature Granulocyte Percentage in the Setting of Possible Infection Principle Investigators

Daniel Hershberger  1 , Kaeli Samson  2 , M Ahsan Saeed  3
Affiliations

Comparison of Band Percentage vs Immature Granulocyte Percentage in the Setting of Possible Infection Principle Investigators

Daniel Hershberger et al. Adv Hematol. .

Abstract

Background: Sepsis is a major cause of mortality worldwide. Early identification and treatment are critical to improve survival. Band count has been used as part of SIRS criteria for the early identification of potentially septic patients. Unfortunately, band count requires manual interpretation. This leads to increased potential for intraobserver variability. Immature granulocytes are counted in an automated fashion, which has the potential to improve accuracy and reduce costs. Research Objective: We aim to compare the band percentage and immature granulocyte percentage to set the threshold for immature granulocyte percentage equal to the sensitivity of > 10% band count. Methods: A retrospective chart review was conducted at a single academic medical center. Data from patients with SIRS criteria and measured immature granulocyte and band percentages were utilized to explore potential associations between immature granulocyte percentages and band percentages. Data were analyzed using Spearman correlations, Wilcoxon rank-sum tests, and logistic regressions. Results: We found no significant associations between immature granulocyte percentage and band percentage or other SIRS criteria. Conclusion: We conclude that immature granulocyte percentage does not correlate with band percentage in the setting of possible infection.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Scatter plot of raw immature granulocyte (%) by raw bands (%).
Figure 2
Figure 2
A receiver operator characteristic curve for a logistic model where dichotomous band percentage was the outcome (greater than 10%, or less than or equal to 10%) and raw immature granulocyte was the only variable in the model. A value of 0.50 is equivalent to chance, while a value of 1.00 represents perfect classification.
Figure 3
Figure 3
Scatter plot of immature granulocyte (%) by band (%). Patients who died within 30 days of first meeting SIRS criteria are indicated in red triangles, while those who did not die within 30 days are indicated with circles.
Figure 4
Figure 4
Vertical box plots of immature granulocyte (%) by 30-day mortality (where the 30-day period starts when patients first meet SIRS criteria).
See this image and copyright information in PMC

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References

    1. Bone R. C., Balk R. A., Cerra F. B., et al. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest . 1992;101(6):1644–1655. doi: 10.1378/chest.101.6.1644. - DOI - PubMed
    1. Cavallazzi R., Bennin C. L., Hirani A., Gilbert C., Marik P. E. Is the Band Count Useful in the Diagnosis of Infection? an Accuracy Study in Critically Ill Patients. Journal of Intensive Care Medicine . 2010;25(6):353–357. doi: 10.1177/0885066610377980. - DOI - PubMed
    1. Zhu L., Chen G., Xia Q., et al. Use of Band Cell Percentage as an Early Predictor of Death and ICU Admission in Severe Acute Pancreatitis. Hepato-Gastroenterology . 2010;57(104):1543–1548. - PubMed
    1. Senthilnayagam B., Kumar T., Sukumaran J., M J., Rao K R. Automated Measurement of Immature Granulocytes: Performance Characteristics and Utility in Routine Clinical Practice. Pathology Research International . 2012;2012:483670–6. doi: 10.1155/2012/483670. - DOI - PMC - PubMed
    1. van der Geest P. J., Mohseni M., Brouwer R., van der Hoven B., Steyerberg E. W., Groeneveld A. J. Immature Granulocytes Predict Microbial Infection and Its Adverse Sequelae in the Intensive Care Unit. Journal of Critical Care . 2014 Aug;29(4):523–527. doi: 10.1016/j.jcrc.2014.03.033. - DOI - PubMed

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