Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Feb;39(2):1190-1237.
doi: 10.1002/ptr.8409. Epub 2025 Jan 7.

Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways

Wenkai Nie  1 , Hao Fu  1 , Yan Zhang  1 , Huiwen Yang  1 , Bing Liu  1   2
Affiliations
Review

Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways

Wenkai Nie et al. Phytother Res. 2025 Feb.

Abstract

Atopic dermatitis (AD) is a common inflammatory dermatitis of the skin and poses therapeutic challenges due to the adverse reactions and high costs associated with available treatments. In Eastern Asian countries, a plethora of herbal remedies is extensively employed for the alleviation of AD. Many of these botanicals are renowned for their formidable anti-inflammatory properties, contributing to AD management. Chinese herbal medicine (CHM) and its active ingredients exhibit both prophylactic and therapeutic promise against AD by modulating inflammatory response, orchestrating immune system functions, and enhancing antioxidant activities. A comprehensive exploration of the underlying mechanisms involved in CHM treatment can enhance the comprehension of AD pathogenesis and facilitate the development of innovative drugs for AD. This study aims to elucidate the signaling pathways and potential targets implicated in CHM-based treatment of AD, providing a systematic theoretical framework for its application in therapy while serving as a valuable reference for developing more effective and safer AD therapeutic agents.

Keywords: Chinese herbal medicine; active ingredient; anti‐inflammation; atopic dermatitis; signaling pathway.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Abbasi, S., M. Kamalinejad, D. Babaie, et al. 2017. “A New Topical Treatment of Atopic Dermatitis in Pediatric Patients Based on Ficus carica L. (Fig): A Randomized, Placebo‐Controlled Clinical Trial.” Complementary Therapies in Medicine 35: 85–91. https://doi.org/10.1016/j.ctim.2017.10.003.
    1. Ahmad‐Nejad, P., S. Mrabet‐Dahbi, K. Breuer, et al. 2004. “The Toll‐Like Receptor 2 R753Q Polymorphism Defines a Subgroup of Patients With Atopic Dermatitis Having Severe Phenotype.” Journal of Allergy and Clinical Immunology 113, no. 3: 565–567. https://doi.org/10.1016/j.jaci.2003.12.583.
    1. Alenazi, S. D. 2023. “Atopic Dermatitis: A Brief Review of Recent Advances in Its Management.” Dermatology Reports 15, no. 3: 9678. https://doi.org/10.4081/dr.2023.9678.
    1. Alves, C., A. Penedones, D. Mendes, and F. B. Marques. 2022. “The Safety of Systemic Janus Kinase Inhibitors in Atopic Dermatitis: A Systematic Review and Network meta‐Analysis.” European Journal of Clinical Pharmacology 78, no. 12: 1923–1933. https://doi.org/10.1007/s00228‐022‐03400‐4.
    1. An, E. J., Y. Kim, S. H. Lee, S. H. Choi, W. S. Chung, and H. J. Jang. 2020. “Ophiopogonin D Ameliorates DNCB‐Induced Atopic Dermatitis‐Like Lesions in BALB/c Mice and TNF‐Alpha‐Inflamed HaCaT Cell.” Biochemical and Biophysical Research Communications 522, no. 1: 40–46. https://doi.org/10.1016/j.bbrc.2019.10.190.

MeSH terms

Substances

LinkOut - more resources