Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 10;13(12):1506.
doi: 10.3390/antiox13121506.

Green Tea Catechins and Skin Health

Xin-Qiang Zheng  1 , Xue-Han Zhang  1 , Han-Qing Gao  1 , Lan-Ying Huang  1 , Jing-Jing Ye  1 , Jian-Hui Ye  1 , Jian-Liang Lu  1 , Shi-Cheng Ma  2 , Yue-Rong Liang  1
Affiliations
Review

Green Tea Catechins and Skin Health

Xin-Qiang Zheng et al. Antioxidants (Basel). .

Abstract

Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves (Camellia sinensis (L.) O. Kuntze). They have garnered significant attention due to their diverse health benefits and potential therapeutic applications, including as antioxidant and sunscreen agents. Human skin serves as the primary barrier against various external aggressors, including pathogens, pollutants, and harmful ultraviolet radiation (UVR). Skin aging is a complex biological process influenced by intrinsic factors such as genetics and hormonal changes, as well as extrinsic factors like environmental stressors, among which UVR plays a pivotal role in accelerating skin aging and contributing to various dermatological conditions. Research has demonstrated that GTCs possess potent antioxidant properties that help neutralize free radicals generated by oxidative stress. This action not only mitigates cellular damage but also supports the repair mechanisms inherent in human skin. Furthermore, GTCs exhibit anti-carcinogenic effects by inhibiting pathways involved in tumor promotion and progression. GTCs have been shown to exert anti-inflammatory effects through modulation of inflammatory signaling pathways. Chronic inflammation is known to contribute significantly to both premature aging and various dermatological diseases such as psoriasis or eczema. By regulating these pathways effectively, GTCs may alleviate symptoms associated with inflammatory conditions. GTCs can enhance wound healing processes by stimulating angiogenesis. They also facilitate DNA repair mechanisms within dermal fibroblasts exposed to damaging agents. The photoprotective properties attributed to GTCs further underscore their relevance in skincare formulations aimed at preventing sun-induced damage. Their ability to screen UV light helps shield underlying tissues from harmful rays. This review paper aims to comprehensively examine the beneficial effects of GTCs on skin health through an analysis encompassing in vivo and in vitro studies alongside insights into molecular mechanisms underpinning these effects. Such knowledge could pave the way for the development of innovative strategies focused on harnessing natural compounds like GTCs for improved skincare solutions tailored to combat environmental stresses faced by the human epidermis.

Keywords: Camellia sinensis; angiogenesis; anti-carcinogenesis; anti-inflammation; antioxidation; signaling pathway; skin care; ultraviolet radiation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Molecular structure of partial catechins.
Figure 2
Figure 2
Antiproliferative effects on skin cancer cells. Red arrows indicate increases, and green arrows indicated decreases.
Figure 3
Figure 3
Effects of GTCs on closure of skin wounds.
Figure 4
Figure 4
DNA protection effects of GTCs.
Figure 5
Figure 5
Effects of GTCs in promoting angiogenesis.
Figure 6
Figure 6
Effects of GTCs in regulating immune responses.
Figure 7
Figure 7
Beneficial effects of GTCs on skin health.
See this image and copyright information in PMC

References

    1. Farage M.A., Miller K.W., Elsner P., Maibach H.I. Intrinsic and extrinsic factors in skin ageing: A review. Int. J. Cosmet. Sci. 2008;30:87–95. doi: 10.1111/j.1468-2494.2007.00415.x. - DOI - PubMed
    1. Katiyar S.K. UV-induced immune suppression and photocarcinogenesis: Chemoprevention by dietary botanical agents. Cancer Lett. 2007;255:1–11. doi: 10.1016/j.canlet.2007.02.010. - DOI - PMC - PubMed
    1. Messaoud M., Marsiquet C., Revol-Cavalier F., Rat V., Marchand G. Flexible sensors for real-time monitoring of moisture levels in wound dressings. J. Wound Care. 2018;27:385–391. doi: 10.12968/jowc.2018.27.6.385. - DOI - PubMed
    1. Avadhani K.S., Manikkath J., Tiwari M., Chandrasekhar M., Godavarthi A., Vidya S.M., Hariharapura R.C., Kalthur G., Udupa N., Mutalik S. Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage. Drug Deliv. 2017;24:61–74. doi: 10.1080/10717544.2016.1228718. - DOI - PMC - PubMed
    1. Farrar M.D., Nicolaou A., Clarke K.A., Mason S., Massey K.A., Dew T.P., Watson R.E.B., Williamson G., Rhodes L.E. A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation. Am. J. Clin. Nutr. 2015;102:608–615. doi: 10.3945/ajcn.115.107995. - DOI - PMC - PubMed

LinkOut - more resources