Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 11;16(24):4131.
doi: 10.3390/cancers16244131.

Perspectives on the Mature T-Cell Lymphomas in the Middle East: A Comprehensive Review of the Present Status

Mubarak Al-Mansour  1   2 , Syed Sameer Aga  2 , Owen A O'Connor  3
Affiliations
Review

Perspectives on the Mature T-Cell Lymphomas in the Middle East: A Comprehensive Review of the Present Status

Mubarak Al-Mansour et al. Cancers (Basel). .

Abstract

Background: T-cell lymphomas (TCLs) are rare and aggressive malignancies associated with poor outcomes, often because of the development of acquired drug resistance as well as intolerance to the established and often toxic chemotherapy regimens in elderly and frail patients. The many subtypes of TCL are well established to exhibit marked geographic variation. The epidemiology, clinical presentation, diagnosis, prognosis, and treatment of TCLs in the Middle East (ME) are yet to be explored; hence, limited data are available about these entities in this part of the world. Aim: Therefore, in this review article, we aim to discuss the available data regarding the T-cell neoplasms in the ME, including the incidence of specific subtypes of peripheral T-cell lymphoma (PTCL), as well as the trends in survival and treatment, all in an effort to understand the natural history of these complex entities across the ME.

Keywords: Middle East; adult T-cell leukemia/lymphoma; anaplastic large-cell lymphoma; angioimmunoblastic T-cell lymphoma; cutaneous T-cell lymphoma; peripheral T-cell lymphoma.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

References

    1. Varghese M.T., Alsubait S. StatPearls [Internet] StatPearls Publishing; Treasure Island, FL, USA: 2022. T-Cell lymphoma.
    1. Alaggio R., Amador C., Anagnostopoulos I., Attygalle A.D., Araujo I.B.D.O., Berti E., Bhagat G., Borges A.M., Boyer D., Calaminici M., et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: Lymphoid neoplasms. Leukemia. 2022;36:1720–1748. doi: 10.1038/s41375-022-01620-2. - DOI - PMC - PubMed
    1. Park H.S., McIntosh L., Braschi-Amirfarzan M., Shinagare A.B., Krajewski K.M. T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes. Korean J. Radiol. 2017;18:71–83. doi: 10.3348/kjr.2017.18.1.71. - DOI - PMC - PubMed
    1. Campo E., Jaffe E.S., Cook J.R., Quintanilla-Martinez L., Swerdlow S.H., Anderson K.C., Brousset P., Cerroni L., de Leval L., Dirnhofer S., et al. The international consensus classification of mature lymphoid neoplasms: A report from the clinical advisory committee. Blood J. Am. Soc. Hematol. 2022;140:1229–1253. doi: 10.1182/blood.2022015851. - DOI - PMC - PubMed
    1. Broccoli A., Zinzani P.L. Peripheral T-cell lymphoma, not otherwise specified. Blood J. Am. Soc. Hematol. 2017;129:1103–1112. doi: 10.1182/blood-2016-08-692566. - DOI - PubMed

LinkOut - more resources