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Review
. 2024 Dec 19;14(12):1634.
doi: 10.3390/biom14121634.

Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment

Yunxia Bao  1   2 , Xianzhao Wang  1 , Bingjie Zeng  1 , Yichun Shi  1 , Yiman Huang  1   3 , Yiwen Huang  1 , Shuang Shang  1 , Liang Shan  1 , Lifang Ma  1   2
Affiliations
Review

Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment

Yunxia Bao et al. Biomolecules. .

Abstract

Liquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the heterogeneity of the tumors. DNA methylation, which is a type of epigenetic modification, is essential in the progression of tumors. This review introduces the common DNA methylation analysis methods and discusses their advantages and disadvantages, focusing on the new progress of DNA methylation-based liquid biopsy in tumor diagnosis and treatment.

Keywords: DNA methylation; epigenetic; liquid biopsy; tumor.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Common DNA methylation analysis workflow, including sample collection, sample disposal, and several common methods of sample detection.
Figure 2
Figure 2
Genes associated with DNA methylation in head tumors currently applied in clinical and research phases.
Figure 3
Figure 3
Genes associated with DNA methylation in thoracic tumors currently applied in clinical and research phases.
Figure 4
Figure 4
Genes associated with DNA methylation in abdominal tumors currently applied in clinical and research phases.
See this image and copyright information in PMC

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