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Review
. 2024 Dec 13;25(24):13384.
doi: 10.3390/ijms252413384.

Innovative Biotherapies and Nanotechnology in Osteoarthritis: Advancements in Inflammation Control and Cartilage Regeneration

Binhan Liu  1 , Tao Liu  1 , Yanhong Li  1 , Chunyu Tan  1
Affiliations
Review

Innovative Biotherapies and Nanotechnology in Osteoarthritis: Advancements in Inflammation Control and Cartilage Regeneration

Binhan Liu et al. Int J Mol Sci. .

Abstract

Osteoarthritis (OA) is among the most prevalent degenerative joint disorders worldwide, particularly affecting the aging population and imposing significant disability and economic burdens. The disease is characterized by progressive degradation of articular cartilage and chronic inflammation, with no effective long-term treatments currently available to address the underlying causes of its progression. Conventional therapies primarily manage symptoms such as pain and inflammation but fail to repair damaged tissues. Emerging biotherapies and regenerative medicine approaches offer promising alternatives by addressing cartilage repair and inflammation control at the molecular level. This review explores the recent advancements in biotherapeutic strategies, including mesenchymal stem cell (MSC) therapy, growth factors, and tissue engineering, which hold the potential for promoting cartilage regeneration and modulating the inflammatory microenvironment. Additionally, the integration of nanotechnology has opened new avenues for targeted drug delivery systems and the development of innovative nanomaterials that can further enhance the efficacy of biotherapies by precisely targeting inflammation and cartilage damage. This article concludes by discussing the current clinical applications, the ongoing clinical trials, and the future research directions necessary to confirm the safety and efficacy of these advanced therapies for OA management. With these advancements, biotherapies combined with nanotechnology may revolutionize the future of OA treatment by offering precise and effective solutions for long-term disease management and improved patient outcomes.

Keywords: biotherapies; cartilage repair; inflammation; nanotechnology; osteoarthritis; regenerative medicine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical manifestations of OA.
Figure 2
Figure 2
Biological treatment of OA. Biological therapy for OA refers to the use of biologics or bioengineering methods to treat OA. These therapies can include biological products such as biological agents, growth factors, stem cell therapy, gene therapy, and others.
Figure 3
Figure 3
Application of nanotechnology in OA.
See this image and copyright information in PMC

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