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. 2024 Dec 16;25(24):13487.
doi: 10.3390/ijms252413487.

The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies

Mihaela Butiulca  1   2 , Lenard Farczadi  3 , Camil Eugen Vari  4 , Silvia Imre  3   5 , Leonard Azamfirei  1   2 , Alexandra Lazar  1   2
Affiliations

The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies

Mihaela Butiulca et al. Int J Mol Sci. .

Abstract

Ropivacaine, a widely used regional anesthetic also used for pain management, has been increasingly used in recent years due to its increased efficacy and improved safety compared to similar anesthetics. Biomonitoring of ropivacaine and its metabolites during and after anesthesia is an essential process for ensuring therapeutic efficacy and safe usage for patients. The most useful biomonitoring tool in recent years has been liquid chromatography coupled with mass spectrometry (LC-MS/MS), which offers selectivity, sensitivity, as well as accuracy of measurements. The current manuscript summarizes and discusses the existing liquid chromatographic methods described in the literature, as well as the personal experience with developing bioanalytical and analytical methods for the quantification of ropivacaine in biological samples for clinical applications. It is focused on methodological aspects, recent advancements, challenges, and future perspectives, highlighting the importance of LC-MS/MS techniques in ropivacaine analysis.

Keywords: HPLC LC MS/MS; regional anesthesia; ropivacaine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structure of mepivacaine. Chiral carbon atom is marked with asterisk.
Figure 2
Figure 2
Chemical structure of ropivacaine. Chiral carbon atom is marked with asterisk.
Figure 3
Figure 3
Chemical structure of bupivacaine. Chiral carbon atom is marked with asterisk.
Figure 4
Figure 4
PRISMA flow diagram of databases research [33] (** processed by human).
See this image and copyright information in PMC

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